Clinical trial Recruiting at 3 sites Interventional Ages 21 to 99 Women only

Exercise program for breast cancer patients

Official title: Breast Cancer Exercise Intervention Study (BREXINT)

Run by National Cancer Centre, Singapore · NCT05957068 · Data updated 2026-11-12

This study tests whether a 24-week exercise program can improve fitness, strength, and quality of life for breast cancer patients who have finished their treatment.

Quick facts

Study typeInterventional
Ages21 Years to 99 Years
SexWomen only
Enrollment2156 (estimated)
SponsorNational Cancer Centre, Singapore
Academic / other
Drugs / interventionschemotherapy
Locations3 sites (Singapore and 2 other locations)
StatusRecruiting
StartedJuly 1, 2023
Main results expectedMay 31, 2028
Study endsMay 31, 2033
Registry record updatedSeptember 5, 2025
Trial IDNCT05957068 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are females aged 21 and older with stage 1, 2, or 3 breast cancer who have recently undergone curative surgery and completed any necessary adjuvant treatments.

Probably not a fit

Patients with significant cardiovascular, respiratory, or musculoskeletal issues that prevent moderate physical activity may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial involves a 24-week exercise program designed for patients with early-stage and locally advanced breast cancer who have undergone curative surgery and completed chemotherapy or radiotherapy. The program includes aerobic exercise and muscle strength training, with the first nine sessions supervised in person by physiotherapists, followed by remote monitoring or supervision at local gyms. The study aims to assess the impact of this exercise intervention on cardiorespiratory fitness, muscle strength, and quality of life among participants. Blood samples and questionnaires will be collected periodically to evaluate health outcomes.

Why it matters

Potential benefit: If successful, this program could enhance physical fitness and quality of life for breast cancer survivors.

How similar studies have gone: Other studies have shown positive outcomes with exercise interventions for cancer patients, indicating potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with histologically or cytologically proven stage 1, 2, or 3 breast cancer
* Patients who have undergone curative breast surgery
* Patients who have received (neo)adjuvant chemotherapy (if given) and/or radiotherapy (if given)
* Females aged 21 years and older
* ≤ 8 weeks from breast surgery, or the last adjuvant chemotherapy or radiotherapy session, whichever is latest.

Exclusion Criteria:

* Cardiovascular, respiratory, musculoskeletal problems that preclude moderate physical activity.
* Major medical problems that are deemed by the investigator to be unsuitable for enrollment.

Where it's running

  • National University Hospital
    Singapore, Singapore
    Recruiting
  • National Cancer Centre
    Singapore, Singapore
    Recruiting
  • Singapore General Hospital
    Singapore, Singapore
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.