Condition

Early-stage Breast Cancer clinical trials and research

• 30Clinical trials
• 6NIH research projects
• 11Countries

Newest Early-stage Breast Cancer clinical trials

All recruiting trials (30)

• One-week versus three-week partial breast irradiation for early-stage breast cancer

  This trial tests whether a shorter one-week partial breast irradiation plan is not worse than a three-week plan for women after breast-conserving surgery.

  Recruiting Fudan University · Shanghai · NCT07832279

• Culmerciclib with endocrine therapy before surgery for early HER2-negative hormone receptor-positive breast cancer

  This trial tests whether adding culmerciclib to an aromatase inhibitor before surgery helps women with certain early breast cancers better shrink tumors than an aromatase inhibitor alone.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07796880

• Partial Breast Radiation After Breast-Conserving Surgery Without Sentinel Node Biopsy

  This pilot study tests whether partial breast irradiation is safe for women who had breast-conserving surgery without sentinel lymph node biopsy or axillary dissection.

  Recruiting NYU Langone Health · New York, New York · NCT07723209

• CDK4/6 inhibitors with endocrine therapy before surgery for HR+/HER2- high-risk early breast cancer

  This study tests whether adding a CDK4/6 inhibitor to endocrine therapy before surgery can help guide safer de-escalation of chemotherapy using ctDNA as a marker.

  Recruiting Phase 2 Peking University People's Hospital · Beijing, Beijing Municipality · NCT07366112

• Exercise and Quality of Life for Early-Stage Hormone Receptor–Positive/HER2-Negative Breast Cancer on Adjuvant Therapy

  This Spain-based trial tests whether a combined resistance and aerobic exercise program improves quality of life for women with early-stage HR+/HER2− breast cancer who are on adjuvant endocrine therapy, with or without a CDK4/6 inhibitor.

  Recruiting at 3 sites Spanish Breast Cancer Research Group · L'Hospitalet de Llobregat, Barcelona and 4 other locations · NCT07215364

• Using blood-based tumor DNA (ctDNA) to find leftover breast cancer after treatment

  This research will test whether a simple blood test that looks for tiny bits of tumor DNA can tell if people treated for breast cancer (including HR+/HER2-, HER2+, and triple-negative) still have leftover cancer or are at risk of recurrence.

  Recruiting at 16 sites Tempus AI · Birmingham, Alabama and 15 other locations · NCT07211178

• Switching aromatase inhibitors versus guideline-based side-effect care to help with AI side effects

  This test tries switching one aromatase inhibitor to another versus using guideline-based side-effect care to see which helps postmenopausal women with early-stage ER-positive breast cancer stay on their hormone therapy.

  Recruiting Phase 2 Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT07071038

• ctDNA-guided reduction of chemotherapy using dalpiciclib plus endocrine therapy in high-risk HR+/HER2- early breast cancer

  This trial tests whether giving the CDK4/6 drug dalpiciclib with endocrine therapy and using ctDNA results can let some women with early high-risk HR+/HER2- breast cancer skip or reduce chemotherapy.

  Recruiting Phase 2 Peking University People's Hospital · Beijing, Beijing Municipality · NCT06970912

• Radiation therapy for early-stage breast cancer using a shorter treatment schedule

  This study is testing a shorter radiation treatment schedule for women 50 and older with early-stage breast cancer to see if it is safe and effective while reducing the number of visits needed.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06902311

• Using Biolosion with standard therapy to treat triple-negative breast cancer

  This study is testing if adding a new oral probiotic called Biolosion to standard treatment can help women with locally advanced triple-negative breast cancer have better outcomes.

  Recruiting Phase 2 Sun Yat-sen University · Lanzhou, Gansu and 4 other locations · NCT06768931

• Water-only fasting to improve chemotherapy for early-stage breast cancer

  This study is testing if fasting for 24-48 hours can help make chemotherapy work better and be easier to tolerate for people with early-stage breast cancer.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia · NCT06536881

• HER2DX-guided treatment for early-stage HER2-positive breast cancer

  This test tries to see if using the HER2DX diagnostic assay to guide personalized treatment can improve quality of life and outcomes for people with early-stage HER2-positive breast cancer.

  Recruiting at 29 sites Fundacio Clinic Barcelona · Graz and 28 other locations · NCT06446882

• Ketorolac and pregabalin to modify perioperative inflammation and nerve signaling in early ER+ breast cancer

  This trial will test whether giving short-term ketorolac, pregabalin, or both around surgery can blunt inflammatory and neural signals in adults having surgery for early estrogen-receptor–positive breast cancer.

  Recruiting Phase 2 Jules Bordet Institute · Brussels · NCT06150898

• Combining Pyrotinib and Capecitabine for HER2 Positive Early-stage Breast Cancer Treatment

  This study is testing if combining two drugs, Pyrotinib and Capecitabine, can help women with early-stage HER2 positive breast cancer after surgery feel better compared to other treatments their doctors choose.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06035016

• Exercise program for breast cancer patients

  This study tests whether a 24-week exercise program can improve fitness, strength, and quality of life for breast cancer patients who have finished their treatment.

  Recruiting at 3 sites National Cancer Centre, Singapore · Singapore and 2 other locations · NCT05957068

• Genomics-guided precision oncology for early high-risk breast cancer

  This study is testing if analyzing the genes of early-stage breast cancer tumors can help find better treatment options for patients who don't respond well to standard chemotherapy.

  Recruiting at 11 sites German Cancer Research Center · Augsburg and 11 other locations · NCT05906407

• Treatment for hormone receptor positive HER2 positive breast cancer after neoadjuvant therapy

  This study is testing if combining two drugs, trastuzumab and nelatinib, can help people with hormone receptor positive HER2 positive breast cancer who still have cancer after initial treatment feel better compared to the usual combination of trastuzumab and pertuzumab.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou · NCT05760612

• Evaluating the need for G-CSF in breast cancer patients on chemotherapy

  This study is testing if breast cancer patients on a specific chemotherapy can skip a medication called G-CSF to see if it helps reduce side effects without affecting their treatment success.

  Recruiting at 3 sites Phase 4 Ottawa Hospital Research Institute · Kingston, Ontario and 2 other locations · NCT05753618

• Precision neoadjuvant therapy for operable breast cancer

  This study is testing if a personalized treatment approach using new drugs for operable breast cancer can work better than standard chemotherapy alone.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT05582499

• Using statins to reduce heart problems in breast cancer patients receiving HER2 therapy

  This study is testing if adding a cholesterol-lowering medication called Lipitor can help protect the hearts of women with early-stage HER2 positive breast cancer who are getting treatment.

  Recruiting at 9 sites Phase 2 Rutgers, The State University of New Jersey · Elizabeth, New Jersey and 9 other locations · NCT05559164

• Screening program for heart and metabolic health in breast cancer survivors

  This study is testing a screening program for women who have survived early-stage breast cancer to see if it helps identify and manage heart and metabolic health risks like diabetes and heart disease.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05386719

• Optimizing post-surgery treatments for early-stage breast cancer using MRD strategy

  This study is testing if using a new strategy based on minimal residual disease can help improve post-surgery treatment for early-stage breast cancer patients by giving more intensive therapy to those at higher risk.

  Recruiting at 2 sites Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality and 2 other locations · NCT05345860

• Genomics-guided therapy for early breast cancer after initial treatment

  This study is testing if personalized treatment plans based on genetic information can help people with early-stage breast cancer who didn't fully respond to initial therapy avoid relapse.

  Recruiting at 7 sites Phase 2 German Cancer Research Center · Heidelberg, Baden-Wurttemberg and 8 other locations · NCT05332561

• Preoperative low dose azacitidine for high-risk early stage breast cancer

  This study is testing if a low dose of azacitidine can boost the immune response in patients with high-risk early stage breast cancer before they have surgery.

  Recruiting Phase 2 University of Illinois Chicago · Chicago, Illinois · NCT04891068

• Targeted Axillary Dissection for Early-stage Breast Cancer

  This study tests a new surgery method for early-stage breast cancer to see if using a special seed to find and remove positive lymph nodes works better than traditional methods.

  Recruiting at 3 sites Jewish General Hospital · Montreal, Quebec and 2 other locations · NCT04671511

• Registry for Intra-Operative Radiotherapy in Early Stage Breast Cancer

  This study is trying to see if a new type of radiation treatment given during breast surgery is safe and effective for women with early stage breast cancer compared to the usual radiation therapy.

  Recruiting Saint John's Cancer Institute · Santa Monica, California · NCT04603209

• Treatment for early-stage HER2 low, hormone receptor positive breast cancer

  This study is testing whether a new treatment combining trastuzumab deruxtecan and anastrozole can help people with early-stage HER2 low, hormone receptor positive breast cancer do better than just using trastuzumab deruxtecan alone.

  Recruiting at 7 sites Phase 2 Jonsson Comprehensive Cancer Center · Fullerton, California and 8 other locations · NCT04553770

• Exercise therapy to enhance heart health in post-menopausal women after breast cancer treatment

  This study tests how different amounts of aerobic exercise can improve heart health in post-menopausal women who have finished treatment for early-stage breast cancer.

  Recruiting at 2 sites Memorial Sloan Kettering Cancer Center · Hartford, Connecticut and 1 other locations · NCT04458532

• Finding the best radiation dose for early-stage breast cancer before surgery

  This study is testing a shorter and potentially more effective radiation treatment for early-stage breast cancer in women aged 50 and older before they have surgery.

  Recruiting University of Miami · Miami, Florida · NCT04360330

• Personalized treatment for breast cancer using new drug agents

  This study is testing new drug combinations with standard chemotherapy to see which treatments work best for different types of breast cancer based on the specific characteristics of each patient's tumor.

  Recruiting at 32 sites Phase 2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 41 other locations · NCT01042379

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Psilocybin-assisted Psychotherapy for Fear of Cancer Recurrence in Early-Stage Breast Cancer

  A study will test whether a one-time psilocybin-assisted psychotherapy session helps reduce fear of cancer returning in women with early-stage breast cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11344227

• Human duct model that mimics early breast cancer growth

  This project builds an all‑human lab model of breast ducts to show how early breast cancers, especially estrogen receptor–positive tumors, grow and interact with nearby cells.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11313243

• Heart disease risk tools for women treated for early-stage breast cancer

  This project will build and test tools to predict the chance of heart disease in women who have had early-stage breast cancer.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11261182

• Improving treatment decisions for older women with early-stage breast cancer

  This study is looking at how a short treatment before surgery for early-stage breast cancer can help women aged 65 and older, along with their doctors, decide on the best follow-up radiation therapy options, so they can make choices that fit their personal health needs and preferences.

  NIH research University of Virginia · Charlottesville, United States · NIH-10745737

• Creating a tool to help older women decide on chemotherapy for early-stage breast cancer

  This study is creating a helpful tool for older women with early-stage breast cancer to make informed choices about chemotherapy, taking into account their health needs and side effects, so they can feel more confident in discussing their treatment options with their doctors.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10686368

• Improving radiation therapy for early stage breast cancer

  This study is testing a new way to give radiation therapy during breast cancer surgery that uses advanced imaging to better target the treatment, and it's for women with early-stage breast cancer who want to see if this method works better than the usual approach.

  NIH research University of Virginia · Charlottesville, United States · NIH-10463616

Related topics

Quick answers

How many Early-stage Breast Cancer clinical trials are recruiting right now?

30, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (13 trials), China (9 trials), Germany (2 trials), Canada (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 13, Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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