Condition

Localized Prostate Carcinoma clinical trials and research

• 23Clinical trials
• 7Countries

Newest Localized Prostate Carcinoma clinical trials

All recruiting trials (23)

• Exercise after pelvic radiation to see if it lowers colorectal cancer risk

  This study tests whether regular walking therapy after pelvic radiation for prostate cancer can influence markers of colorectal cancer in colon tissue and blood.

  Recruiting at 2 sites City of Hope Medical Center · Duarte, California and 1 other locations · NCT07790718

• PSMA-targeted therapy with hormone suppression for low-volume metastatic prostate cancer

  This phase II trial tests leuprolide acetate alone versus with 177Lu-PSMA-617 (with or without abiraterone acetate and prednisone) in men with hormone-sensitive, low-volume metastatic prostate cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07650240

• MRI-based microboost SBRT with de-escalated whole-gland radiation for localized prostate cancer

  This study tests whether giving a focused 45 Gy microboost to MRI-defined lesions with smaller whole-gland doses (30 or 35 Gy) is safe and effective for men with low- to intermediate-risk localized prostate cancer.

  Recruiting Phase 2 Georgetown University · Washington D.C., District of Columbia · NCT07644598

• Short-term hormone therapy with PSMA PET/CT before prostate removal for high-risk localized prostate cancer

  This trial will test whether giving short-term androgen-deprivation therapy (ADT) before prostate removal lowers PSMA PET signal and helps predict recurrence risk in men with localized high-risk prostate cancer.

  Recruiting Phase 2 Baptist Health South Florida · Miami, Florida · NCT07455903

• Comparing Lutetium-177 and Actinium-225 PSMA-targeted radiation before prostatectomy

  This will test whether giving one of two PSMA-targeted radiation drugs (Lutetium-177 or Actinium-225) before prostate removal works differently in men with high or very high-risk localized prostate cancer.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT07054346

• Wrapping nerves with a multi-layer perinatal tissue graft during prostate removal

  This trial will test whether wrapping the nerves with a multi-layer perinatal tissue allograft during nerve-sparing robotic prostate removal helps men with localized prostate cancer keep erectile and urinary function.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06940271

• Adaptive radiotherapy for localized prostate cancer

  This study is testing a new type of radiation therapy for men with localized prostate cancer who have urinary problems to see if it can safely treat their cancer without causing too many side effects.

  Recruiting University of Zurich · Heidelberg, Baden-Wurttemberg and 2 other locations · NCT06834152

• Testosterone therapy for men with low testosterone and localized prostate cancer on active surveillance

  This study is testing if testosterone therapy can help men with low testosterone and localized prostate cancer feel better and stay safe while they are being monitored for their cancer.

  Recruiting Phase 4 Roswell Park Cancer Institute · Buffalo, New York · NCT06733350

• Tailored survivorship care plans to improve health literacy after prostate cancer

  This will test whether a survivorship care plan designed for people with low health literacy helps Black or African American men who finished treatment for localized or oligometastatic prostate cancer better understand and access follow-up care than a standard plan.

  Recruiting at 3 sites Emory University · Atlanta, Georgia and 2 other locations · NCT06674863

• Two-fraction radiotherapy for localized prostate cancer

  This study is testing if giving radiotherapy in just two sessions instead of five can effectively treat localized prostate cancer while causing fewer side effects for patients.

  Recruiting UMC Utrecht · Utrecht · NCT06518226

• Golf exercise program for prostate cancer survivors

  This study tests whether a 10-week golf exercise program can help prostate cancer survivors feel better physically and mentally.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06500169

• Using advanced imaging to predict lymph node spread in high-risk prostate cancer

  This study is testing a new imaging method to see if it can help doctors predict whether high-risk prostate cancer has spread to lymph nodes before surgery.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06389786

• Comparing two robotic surgery methods for prostate cancer treatment

  This study is testing which of two robotic surgery methods works better for treating localized prostate cancer and helps patients recover faster.

  Recruiting Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT06238713

• Investigating HDR Brachytherapy for Prostate Cancer

  This study is testing how effective High Dose Rate brachytherapy is for treating localized prostate cancer and looking at how it affects tumor changes and the immune system.

  Recruiting British Columbia Cancer Agency · Kelowna, British Columbia · NCT06200974

• Focal ablation treatments for localized prostate cancer

  This study is testing if new focal treatments like cryotherapy and high-intensity ultrasound can effectively treat localized prostate cancer in men and improve their urinary and sexual function over time.

  Recruiting University of California, Davis · Sacramento, California · NCT06178354

• Using PSMA PET scans to improve prostate cancer treatment accuracy

  This study is testing if a new type of PET scan can help men with localized prostate cancer get more accurate treatment before they undergo therapy.

  Recruiting at 4 sites Phase 2 University of Alberta · Calgary, Alberta and 3 other locations · NCT06003556

• High-dose single fraction radiation therapy for prostate cancer

  This study is testing a high-dose radiation treatment for localized prostate cancer to see if it is safe and effective while protecting the urethra.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT05936736

• Magnetic resonance imaging with hyperpolarized bicarbonate to measure tissue pH in localized prostate cancer

  This small pilot study tests whether injecting hyperpolarized 13C bicarbonate before MRI can safely map tissue pH in men with localized prostate cancer.

  Recruiting Early Phase 1 University of California, San Francisco · San Francisco, California · NCT05851365

• Comparing two types of radiation therapy for prostate cancer treatment

  This study is testing whether a new type of radiation therapy for prostate cancer works better and is safer than a different method, while also looking at how well the treatment is tolerated by patients.

  Recruiting CHU de Quebec-Universite Laval · Québec · NCT05786742

• Effects of exercise therapy on prostate cancer indicators

  This study is testing if a home-based walking program can help men with low-risk prostate cancer show better signs of their condition compared to those who stick to their usual exercise routines.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California and 9 other locations · NCT05751434

• High dose rate brachytherapy for localized prostate cancer

  This study is testing a new way to give high dose rate brachytherapy to treat localized prostate cancer in two sessions to see if it's safe for patients with low to intermediate risk.

  Recruiting University of California, San Francisco · San Francisco, California · NCT05665738

• Effects of vitamin D replacement on immune function in Black prostate cancer patients

  This study is testing if giving vitamin D to Black men with prostate cancer can help their immune system work better and improve their overall health.

  Recruiting at 2 sites Early Phase 1 Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT05045066

• Using advanced imaging to detect high-grade prostate cancer

  This study is testing a new type of imaging to see if it can help find high-grade prostate cancer in men before they have surgery or a biopsy.

  Recruiting Early Phase 1 University of California, San Francisco · San Francisco, California · NCT02526368

Related topics

Quick answers

How many Localized Prostate Carcinoma clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (16 trials), Canada (3 trials), Netherlands (1 trial), Germany (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Early Phase 1: 3, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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