Condition

Stage III Prostate Cancer AJCC v8 clinical trials and research

• 19Clinical trials
• 5Countries

Newest Stage III Prostate Cancer AJCC v8 clinical trials

All recruiting trials (19)

• MRI or CT planning to guide high-dose-rate prostate brachytherapy

  This trial tests whether adding an MRI to CT-based treatment planning for HDR prostate brachytherapy changes urinary side effects in men with localized prostate cancer.

  Recruiting at 3 sites Emory University · Atlanta, Georgia and 2 other locations · NCT07859722

• Exercise after pelvic radiation to see if it lowers colorectal cancer risk

  This study tests whether regular walking therapy after pelvic radiation for prostate cancer can influence markers of colorectal cancer in colon tissue and blood.

  Recruiting at 2 sites City of Hope Medical Center · Duarte, California and 1 other locations · NCT07790718

• Image-guided adaptive stereotactic body radiation therapy for localized prostate cancer

  This trial tests whether daily, real-time adaptive image-guided SBRT causes fewer urinary and other side effects than standard non-adaptive SBRT for men with localized prostate cancer.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07276438

• Home versus clinic cancer treatment for Black men with advanced or recurrent prostate cancer

  This Phase II test tries whether giving cancer treatments at home instead of in the clinic is safer and more satisfying for Black men with locally advanced, biochemically recurrent, or metastatic prostate cancer.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07073794

• Relugolix to improve PSMA PET/CT imaging in men with high or very high risk prostate cancer

  We are testing whether a short course of relugolix can boost PSMA levels and make PSMA PET/CT scans better at finding cancer in men with high or very high risk prostate cancer.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT07025369

• Wrapping nerves with a multi-layer perinatal tissue graft during prostate removal

  This trial will test whether wrapping the nerves with a multi-layer perinatal tissue allograft during nerve-sparing robotic prostate removal helps men with localized prostate cancer keep erectile and urinary function.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06940271

• Testosterone therapy for men with low testosterone and localized prostate cancer on active surveillance

  This study is testing if testosterone therapy can help men with low testosterone and localized prostate cancer feel better and stay safe while they are being monitored for their cancer.

  Recruiting Phase 4 Roswell Park Cancer Institute · Buffalo, New York · NCT06733350

• Comparing heart effects of two hormone therapies in advanced prostate cancer

  This study is testing whether two different hormone treatments for advanced prostate cancer affect heart health differently in men receiving radiation therapy.

  Recruiting at 4 sites Phase 3 Emory University · Atlanta, Georgia and 3 other locations · NCT06650579

• Golf exercise program for prostate cancer survivors

  This study tests whether a 10-week golf exercise program can help prostate cancer survivors feel better physically and mentally.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06500169

• Using advanced imaging to predict lymph node spread in high-risk prostate cancer

  This study is testing a new imaging method to see if it can help doctors predict whether high-risk prostate cancer has spread to lymph nodes before surgery.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06389786

• Adaptive radiation therapy for localized prostate cancer

  This study is testing a new type of radiation therapy for localized prostate cancer to see if it can improve patients' quality of life compared to standard treatment.

  Recruiting at 5 sites Mayo Clinic · Albert Lea, Minnesota and 4 other locations · NCT06325046

• Comparing Abiraterone with Prednisone or Darolutamide for Advanced Prostate Cancer

  This study is testing whether a combination of abiraterone and prednisone works better than darolutamide alone for people with advanced prostate cancer by looking at side effects and changes in PSA levels over a year.

  Recruiting Phase 2 University of California, Davis · Sacramento, California · NCT06173362

• Comparing shorter radiation therapy to standard radiation for high-risk prostate cancer

  This study is testing if a shorter, more intense radiation treatment for high-risk prostate cancer can work just as well as the standard longer treatment.

  Recruiting at 431 sites Phase 3 NRG Oncology · Birmingham, Alabama and 435 other locations · NCT05946213

• Using bright white light therapy to reduce fatigue and depression in advanced prostate cancer patients

  This study is testing if bright white light therapy can help reduce fatigue and depression in men with advanced prostate cancer who are receiving treatment.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT05869682

• High-dose vitamin D for bone health in older prostate cancer patients on hormone therapy

  This study is testing if high-dose vitamin D can help older prostate cancer patients on hormone therapy keep their bones strong and reduce the risk of falls and fractures.

  Recruiting at 51 sites Phase 3 University of Rochester · Newark, Delaware and 50 other locations · NCT05838716

• Peer navigation to support African American men with metastatic prostate cancer during genetic testing

  This trial tests whether a trained peer navigator helps African American men with metastatic prostate cancer better understand and complete genetic testing compared with standard care.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT05487846

• Androgen therapy with or without niraparib for high-risk prostate cancer after radiation

  This study is testing whether adding the drug niraparib to hormone therapy after radiation can help men with high-risk prostate cancer do better than hormone therapy alone.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04947254

• Combining high dose-rate brachytherapy and stereotactic body radiotherapy for prostate cancer treatment

  This study is testing whether combining two types of radiation therapy can improve treatment outcomes for men with prostate cancer.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT04945642

• Proton radiation therapy for high-risk prostate cancer

  This study is testing if proton radiation therapy can effectively treat high-risk prostate cancer while causing fewer side effects than traditional radiation methods.

  Recruiting Emory University · Atlanta, Georgia · NCT04725903

Related topics

Quick answers

How many Stage III Prostate Cancer AJCC v8 clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (19 trials), Canada (1 trial), Hong Kong (1 trial), Singapore (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 3, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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