Condition

Stage IVB Prostate Cancer AJCC v8 clinical trials and research

• 28Clinical trials
• 6Countries

Newest Stage IVB Prostate Cancer AJCC v8 clinical trials

All recruiting trials (28)

• Measuring ctDNA to guide stopping 177Lu-PSMA-617 in metastatic prostate cancer

  This trial tests whether ctDNA tumor fraction can help decide when to stop 177Lu-PSMA-617 in men with metastatic castration-resistant prostate cancer.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07698535

• PSMA-targeted therapy with hormone suppression for low-volume metastatic prostate cancer

  This phase II trial tests leuprolide acetate alone versus with 177Lu-PSMA-617 (with or without abiraterone acetate and prednisone) in men with hormone-sensitive, low-volume metastatic prostate cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07650240

• Estrogen-Plus-ARSI for Hormone-Sensitive Metastatic Prostate Cancer

  This phase 2 study tests whether adding transdermal estrogen to an androgen receptor signaling inhibitor improves quality of life for adults with newly diagnosed or recurrent metastatic hormone sensitive prostate cancer.

  Recruiting Phase 2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT07466498

• Combining lutetium‑177 PSMA therapy with sipuleucel‑T for advanced castration‑resistant prostate cancer

  This trial tests whether adding sipuleucel‑T to lutetium‑177 PSMA‑617 helps men with metastatic castration‑resistant prostate cancer.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT07219147

• Testing Different Dosing Schedules of Lutetium-177Lu PSMA RLT in Advanced Prostate Cancer

  This trial tests if spacing out Lutetium-177Lu PSMA RLT doses adapts to the patient and improves quality of life without shortening life in men with advanced, hormone-resistant prostate cancer.

  Recruiting at 105 sites Phase 3 Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 141 other locations · NCT07200830

• Using 18F-TRX to image solid tumors

  This trial tests whether the 18F-TRX PET tracer can detect tumors in adults with advanced solid tumors such as high‑grade glioma, clear cell renal cell carcinoma, or metastatic castration‑resistant prostate cancer.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06942104

• Adding docetaxel to hormonal therapy and apalutamide for metastatic prostate cancer

  This trial tests whether giving the chemotherapy drug docetaxel in addition to hormone therapy and apalutamide helps men with metastatic castration-sensitive prostate cancer live longer.

  Recruiting at 208 sites Phase 3 Alliance for Clinical Trials in Oncology · Tucson, Arizona and 213 other locations · NCT06931340

• Tailored survivorship care plans to improve health literacy after prostate cancer

  This will test whether a survivorship care plan designed for people with low health literacy helps Black or African American men who finished treatment for localized or oligometastatic prostate cancer better understand and access follow-up care than a standard plan.

  Recruiting at 3 sites Emory University · Atlanta, Georgia and 2 other locations · NCT06674863

• Targeted treatment for advanced prostate cancer

  This study is testing whether using genetic testing to guide treatment can help people with advanced prostate cancer respond better to new medications.

  Recruiting at 98 sites Phase 2 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 107 other locations · NCT06632977

• Combining ruxolitinib and enzalutamide for advanced prostate cancer treatment

  This study is testing if combining two medications, ruxolitinib and enzalutamide, can safely help men with advanced prostate cancer that hasn't responded to hormone therapy.

  Recruiting Phase 1/2 University of Michigan Rogel Cancer Center · Chicago, Illinois and 2 other locations · NCT06616155

• Intensified treatment for advanced prostate cancer using 177Lu-PSMA-617

  This study is testing a new treatment called 177Lu-PSMA-617 for men with advanced prostate cancer that doesn't respond to hormone therapy to see if it works better than the usual treatments.

  Recruiting at 2 sites Phase 2 University of Washington · San Francisco, California and 2 other locations · NCT06526299

• Combining Carboplatin with Cabazitaxel for Advanced Prostate Cancer

  This study is testing if adding carboplatin to cabazitaxel chemotherapy can help men with advanced prostate cancer live longer and feel better compared to just using cabazitaxel alone.

  Recruiting at 174 sites Phase 3 SWOG Cancer Research Network · Fayetteville, Arkansas and 173 other locations · NCT06470243

• Re-treatment with a radioactive drug for advanced prostate cancer

  This study is testing if giving a radioactive drug again can help men with advanced prostate cancer who did well on it before feel better and live longer.

  Recruiting Phase 2 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06288113

• Using PET scans to guide radiation therapy for metastatic prostate cancer

  This study is testing if using PET scans to guide radiation therapy can help men with metastatic prostate cancer live longer and have better treatment outcomes compared to standard treatments alone.

  Recruiting at 5 sites Phase 2 Northwestern University · Chicago, Illinois and 5 other locations · NCT06244004

• Cell therapy combined with enzalutamide for advanced prostate cancer

  This study is testing a new combination of cell therapy and a medication called enzalutamide to see if it helps people with advanced prostate cancer live better and longer.

  Recruiting Phase 1/2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT06236139

• Using vorinostat and a radioactive treatment for low PSMA metastatic prostate cancer

  This study is testing if adding vorinostat to a radioactive treatment can help people with low PSMA metastatic prostate cancer feel better and improve their outcomes.

  Recruiting Phase 2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT06145633

• Using high levels of testosterone to improve treatment for advanced prostate cancer

  This study is testing if raising testosterone levels can make chemotherapy and a specific drug work better for men with advanced prostate cancer that has stopped responding to other treatments.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT06039371

• CAR-T cell therapy with or without radiation for advanced prostate cancer

  This study is testing if a new CAR-T cell therapy, with or without radiation, can help people with advanced prostate cancer live longer and feel better.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT05805371

• Testing a radioactive treatment for metastatic prostate cancer with neuroendocrine cells

  This study is testing a radioactive treatment to see if it can help people with metastatic prostate cancer that has neuroendocrine features feel better and live longer.

  Recruiting at 11 sites Phase 2 National Cancer Institute (NCI) · Duarte, California and 12 other locations · NCT05691465

• Using image-guided biopsies to understand resistance in advanced prostate cancer treatment

  This study is testing how advanced imaging can help doctors understand why some men with hard-to-treat prostate cancer don't respond to a specific therapy, so they can find better treatment options.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT05398302

• Using abemaciclib before a radioactive treatment for advanced prostate cancer

  This study is testing if taking abemaciclib before a radioactive treatment can help men with advanced prostate cancer feel better and improve their treatment results.

  Recruiting Phase 1/2 University of California, San Francisco · San Francisco, California · NCT05113537

• Exercise and Fitbit monitoring for prostate cancer patients on hormone therapy

  This study tests if a 16-week exercise program with Fitbit tracking can help prostate cancer patients on hormone therapy improve their heart health and manage other related health risks.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05054296

• Combining talazoparib with hormone therapy and abiraterone for prostate cancer treatment

  This study is testing if adding a new drug called talazoparib to standard hormone therapy and abiraterone can help men with advanced prostate cancer do better with their treatment.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT04734730

• Combining cryoablation and radiation therapy for painful bone metastases

  This study is testing if combining a freezing treatment with radiation can help people with painful bone cancer feel better compared to just using radiation alone.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04693377

• Investigating DNA Repair and Radium-223 in Advanced Prostate Cancer

  This study is testing if radium-223 can help people with advanced prostate cancer that has spread to the bones, while also looking at how changes in DNA repair might affect the treatment's success.

  Recruiting at 3 sites University of Washington · Baltimore, Maryland and 3 other locations · NCT04489719

• Combining Apalutamide and Targeted Radiation for Recurrent Prostate Cancer

  This study is testing if combining a new medication with radiation therapy can help men with recurring prostate cancer feel better and live longer after surgery.

  Recruiting at 278 sites Phase 3 Eastern Cooperative Oncology Group · Anchorage, Alaska and 340 other locations · NCT04423211

• Combining immunotherapy and targeted therapy for rare bladder tumors

  This study is testing a new combination of treatments for people with rare bladder tumors that have spread, to see if it helps them live longer and feel better.

  Recruiting at 222 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 581 other locations · NCT03866382

• Comparing standard therapy with or without surgery or radiation for metastatic prostate cancer

  This study is testing whether adding surgery or radiation to standard treatment helps men with metastatic prostate cancer live longer and feel better compared to just standard treatment alone.

  Recruiting at 297 sites Phase 3 SWOG Cancer Research Network · Gilbert, Arizona and 337 other locations · NCT03678025

Related topics

Quick answers

How many Stage IVB Prostate Cancer AJCC v8 clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (28 trials), Puerto Rico (1 trial), Chile (1 trial), Colombia (1 trial), Mexico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 13, Phase 3: 5, Phase 1: 4, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →