How Lipedema Affects Knee Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will compare two groups of women aged 30-65 with knee osteoarthritis: those who also have lipedema and those who do not. The researchers will look at clinical symptoms and ultrasonographic measurements to determine the independent impact of lipedema on knee osteoarthritis. By analyzing these factors within the same osteoarthritis context, the study aims to inform earlier diagnosis and targeted rehabilitation strategies. No interventions are described; the study focuses on comparative assessment and characterization. The investigation is conducted at Izmir Democracy University in Izmir, Turkey.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All participants (Group 1 + Group 2)

* Women aged 30-65
* With a clinical and radiological diagnosis of knee osteoarthritis
* Who agreed to participate in the study

Group 1 (knee osteoarthritis with lipedema):

* Patients who meet the Wold criteria for a clinical diagnosis of lipedema
* An increase in subcutaneous fat thickness confirmed by ultrasound

Group 2 (knee osteoarthritis without lipedema):

* No diagnosis of lipedema
* Exclusion of lymphedema and venous diseases

Exclusion Criteria:

* Inflammatory arthritis
* History of knee surgery
* Intra-articular injection within the past 6 months
* Acute trauma
* Systemic connective tissue disease
* Severe venous insufficiency or lymphedema
* History of malignancy
* Use of gabapentinoids/SNRIs/SSRIs due to fibromyalgia or psychiatric illness
* Severe cognitive impairment or communication problems that would prevent participation in the study
* Pregnancy
* Participants who were informed about the study and refused to participate

Where it's running

• Izmir Democracy University
  Izmir, İzmir, Turkey (Türkiye) Recruiting
• Izmir Democracy University
  Izmir, İzmir, Turkey (Türkiye) Not yet recruiting

Study contacts

• Study coordinator: Kadir Songür, Assoc. Prof.
• Email: kadir.93@gmail.com
• Phone: +905054529231

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.