Radial Shock Wave Therapy for knee bone marrow edema in people with knee OA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares radial extracorporeal shock wave therapy (ESWT) to sham ESWT in adults with knee OA and MRI-confirmed bone marrow edema around the knee. Participants have Kellgren–Lawrence grade 2–3 OA, unilateral BME in a knee compartment, and meet safety criteria. The treatment aims to improve pain and function by improving blood flow and promoting bone remodeling, without invasive procedures. Outcomes are assessed using symptom questionnaires and imaging as appropriate. Recruitment is centered at Dokuz Eylul University in Izmir, Turkey.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 40-70 years
* Radiographic evidence of knee osteoarthritis classified as Kellgren-Lawrence grade 2 or 3
* Unilateral BME in the bones around the knee, limited to either the medial or lateral compartment of the knee joint, as confirmed by MRI. The affected sites may include the medial femoral condyle, medial tibial plateau, or both; or the lateral femoral condyle, lateral tibial plateau, or both
* Willingness to participate in the study
* Provision of written informed consent

Exclusion Criteria:

* Insufficient cognitive ability to complete the questionnaires
* Physical therapy, corticosteroid injection, or surgery involving the affected area within the previous 6 months
* Previous ESWT treatment
* Open wounds, infection, bleeding, skin lesions, or metal implants around the knee
* Presence of a cardiac pacemaker
* Peripheral arterial occlusive disease
* Polyneuropathy or sensory impairment
* Inflammatory rheumatic disease
* Severe cardiovascular disease
* Pregnancy
* History of epilepsy
* History of malignancy
* Bleeding disorders

Where it's running

• Dokuz Eylul University
  Izmir, Balcova, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Tugba Sahin, MD
• Email: tugba.senturk@deu.edu.tr
• Phone: +902324123951

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Perturbation-based balance training vs progressive neuromuscular training alongside standard physiotherapy for knee osteoarthritis

  This trial tests whether perturbation-based balance training adds benefit over progressive neuromuscular training when used with usual physiotherapy for people with knee osteoarthritis and chronic knee pain.

  Recruiting Ibadat International University, Islamabad · Islamabad, ICT · NCT07653841

• Single-center, first-in-human injection of ceAF for knee osteoarthritis

  This early-stage study tests a single knee injection of ceAF to see if it is safe and helps reduce pain and improve function in adults with knee osteoarthritis.

  Recruiting Phase 1 Anhui HygeianCells BioMedical Co., Ltd. · Huangshan City, Anhui · NCT07902128

• Motivational Interviewing Plus Exercise for knee osteoarthritis

  This study tests whether adding motivational interviewing to a neuromuscular and home exercise program helps people with knee osteoarthritis improve pain control and get more active.

  Recruiting Kutahya Health Sciences University · Afyonkarahisar, Türkiye · NCT07767812

• How patient education helps people with chronic musculoskeletal pain stick to home exercise for pain relief

  A structured patient education program is tested to see if it helps people with chronic low back pain, knee osteoarthritis, and shoulder problems stick with their home exercise plan to relieve pain.

  Recruiting Imam Abdulrahman Bin Faisal University · Dammam, Eastern Province · NCT07764354

• Eccentric gastrocnemius strengthening vs low-load blood flow restriction training for knee osteoarthritis

  This study tests whether eccentric strengthening of the calf muscle or low-load blood flow restriction training can improve strength and function in people with knee osteoarthritis.

  Recruiting Riphah International University · Rawalpindi, Punjab Province · NCT07733518

• Pressure Biofeedback vs Bolster Foam Feedback for Knee Osteoarthritis

  We’re testing whether pressure biofeedback training helps people with knee osteoarthritis improve pain, function, and muscle activation more than bolster foam feedback over eight weeks.

  Recruiting Lahore University of Biological and Applied Sciences · Lahore · NCT07731737

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.