Condition

Narcolepsy Type 1 clinical trials and research

• 15Clinical trials
• 19Countries

Newest Narcolepsy Type 1 clinical trials

All recruiting trials (15)

• Temporal interference stimulation for narcolepsy type 1

  A noninvasive brain stimulation test to see if theta-burst temporal interference can help people with narcolepsy type 1.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07727239

• Long-term test of TAK-360 in people with narcolepsy or idiopathic hypersomnia

  This study tests TAK-360 over an extended period to see if it is tolerable for people with narcolepsy type 1, narcolepsy type 2, or idiopathic hypersomnia who completed an earlier TAK-360 trial.

  Recruiting at 33 sites Phase 2/3 Takeda · Chula Vista, California and 32 other locations · NCT07646678

• TAK-360 in adults with narcolepsy Type 1 with cataplexy

  This study tests TAK-360 versus placebo in adults with narcolepsy Type 1 to see if it is safe and tolerable.

  Recruiting at 9 sites Phase 2 Takeda · Redwood City, California and 17 other locations · NCT07633301

• Test of Cleminorexton vs placebo for central hypersomnolence in NT1/NT2

  This study tests cleminorexton to see if it helps daytime sleepiness in adults with Narcolepsy Type 1 or Type 2 compared with a placebo.

  Recruiting at 26 sites Phase 2/3 Centessa Pharmaceuticals plc · Birmingham, Alabama and 25 other locations · NCT07598708

• ALKS 2680 in adults with narcolepsy type 1: see if it helps daytime sleepiness and cataplexy

  This study tests whether ALKS 2680 helps reduce daytime sleepiness and cataplexy in adults with narcolepsy type 1 compared with a placebo.

  Recruiting at 20 sites Phase 3 Alkermes, Inc. · Brandon, Florida and 19 other locations · NCT07540897

• ALKS 2680 for reducing daytime sleepiness and cataplexy in adults with narcolepsy type 1

  This study will test whether ALKS 2680 tablets can reduce daytime sleepiness, cataplexy, and other symptoms in adults with narcolepsy type 1.

  Recruiting at 44 sites Phase 3 Alkermes, Inc. · Cullman, Alabama and 43 other locations · NCT07455383

• Pain testing for people with idiopathic REM sleep behavior disorder

  This study will test whether people with idiopathic REM sleep behavior disorder feel and report pain differently using brief thermal pain tests and questionnaires.

  Recruiting University Hospital, Toulouse · Toulouse · NCT07365566

• Long-term ORX750 treatment for people with narcolepsy or idiopathic hypersomnia

  This open-label extension will try continued ORX750 treatment in people with narcolepsy or idiopathic hypersomnia who completed the earlier ORX750 parent study.

  Recruiting at 24 sites Phase 2 Centessa Pharmaceuticals (UK) Limited · Auburn, Alabama and 23 other locations · NCT07096674

• Long-term treatment with ALKS 2680 for narcolepsy and idiopathic hypersomnia

  This study is testing how well a new medication called ALKS 2680 works for people with narcolepsy or idiopathic hypersomnia over a long period of time.

  Recruiting at 50 sites Phase 2/3 Alkermes, Inc. · Cullman, Alabama and 49 other locations · NCT06767683

• Testing ORX750 for Narcolepsy and Idiopathic Hypersomnia

  This study is testing a new medication called ORX750 to see if it can help people with narcolepsy or idiopathic hypersomnia feel more awake and improve their daily lives.

  Recruiting at 37 sites Phase 2 Centessa Pharmaceuticals plc · Auburn, Alabama and 36 other locations · NCT06752668

• Understanding how food intake affects sleep in narcolepsy and hypersomnia patients

  This study is testing how what people eat affects their sleep and daytime sleepiness in patients with narcolepsy and hypersomnia to find better ways to manage their health.

  Recruiting Hospices Civils de Lyon · Clermont-Ferrand and 1 other locations · NCT06484348

• Exploring mind-wandering and its effects in narcolepsy and hypersomnolence

  This study is testing how daydreaming affects thinking and creativity in people with narcolepsy and excessive sleepiness.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06457945

• See if a non-drug therapy reduces nightmares in adults with narcolepsy

  This study tests a talking-based therapy called imagery rehearsal therapy to see if it reduces frequent nightmares in adults with narcolepsy, with participants and sometimes their sleep partners involved in assessments.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06383806

• Gut bacteria and bacterial translocation in people with type 1 narcolepsy versus controls

  This study will test whether the gut microbiome and bacterial translocation differ in people with type 1 narcolepsy compared with people without hypersomnolence problems.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes, Gard and 1 other locations · NCT06292598

• Evaluating TAK-861 for treating narcolepsy type 1

  This study is testing a new medication called TAK-861 to see if it can help people with narcolepsy type 1 feel less sleepy during the day and reduce their sudden muscle weakness.

  Recruiting at 52 sites Phase 2/3 Takeda · Birmingham, Alabama and 51 other locations · NCT05816382

Related topics

Quick answers

How many Narcolepsy Type 1 clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (10 trials), France (9 trials), Italy (6 trials), Spain (6 trials), Australia (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 4, Phase 2: 3, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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