Registry for patients with non-ischemic cardiomyopathies
Official title: Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.
Run by Scientific Institute San Raffaele · NCT06607471 · Data updated 2026-11-12
This study is collecting information from people with non-ischemic cardiomyopathies to see how to better diagnose and manage their condition and predict potential heart rhythm problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 15000 (estimated) |
| Sponsor | Scientific Institute San Raffaele Academic / other |
| Locations | 1 site (Milan, Milano) |
| Status | Recruiting |
| Started | January 30, 2018 |
| Main results expected | December 31, 2035 |
| Study ends | December 31, 2035 |
| Registry record updated | September 23, 2024 |
| Trial ID | NCT06607471 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with clinical suspicion or proven diagnosis of any form of non-ischemic cardiomyopathy.
✕Probably not a fit
Patients with proven diagnoses of cardiac diseases other than non-ischemic cardiomyopathy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study collects clinical data from both retrospective and prospective patients suspected or diagnosed with non-ischemic cardiomyopathies (NICM). It aims to improve diagnostic methods, identify disease-specific signatures, and develop risk prediction models for arrhythmic events. The registry will utilize various diagnostic techniques, including genetic testing, cardiac magnetic resonance, and other imaging modalities to enhance understanding and management of NICM. By analyzing a diverse patient population, the study seeks to address unresolved questions in the field of arrhythmogenic-inflammatory NICM.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and personalized treatment strategies for patients with non-ischemic cardiomyopathies.
How similar studies have gone: While similar approaches have been explored, this registry aims to provide a comprehensive and novel perspective on non-ischemic cardiomyopathies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Written informed consent. For pediatric patients, consent will be obtained by parents, according to the laws applicable in each of the participating countries. * Clinical suspicion of NICM, and/or proven diagnosis of any NICM and/or genotype consistent with any NICM. NICMs will include but not limit to: DCM, HCM, RCM, ACM, inflammatory, infiltrative, dysmetabolic, mitochondrial, toxic, neuromuscular, rheumatologic/autoimmune cardiomyopathies, channelopathies with structural substrates, LVNC, PPCM, AMVP, AFD, athlete's heart, undefined and overlap cardiomyopathies. Additional diseases of the NICM spectrum will be included in parallel with the advance of the current knowledge. Exclusion Criteria: * Absent informed consent. * Proven diagnosis of cardiac disease alternative to NICM. * Lack of diagnostic workup suitable for diagnosing NICM, detecting arrhythmias, or detecting M-Infl. * For patients retrospectively enrolled: lack of active status of follow-up at the enrolling center.
Where it's running
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IRCCS San Raffaele Scientific Institute
Milan, Milano, Italy Recruiting
Study contacts
- Study coordinator: Giovanni Peretto, MD
- Email: peretto.giovanni@hsr.it
- Phone: +39 0226437482
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.