High-speed centrifugation to enable anti-Xa testing on lipemic (fatty) blood samples

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Many anti-Xa assays rely on spectrophotometric readings that can be distorted when a sample is lipemic, a problem affecting a small percentage of routine samples. This observational project uses routine adult anti-Xa samples, artificially overloaded with lipids when needed, to see if a high-speed centrifugation step (10,800g for 10 minutes) clears the interference. Samples will come from patients already anticoagulated with agents monitored by anti-Xa (UFH, LMWH, fondaparinux, danaparoid, apixaban, rivaroxaban) and processed at the CHU de Strasbourg hematology laboratory. Samples with pre-existing high baseline lipemia or insufficient volume are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient (≥ 18 years)
* Patient anticoagulated with an anti-Xa (UFH, LMWH, fondaparinux, danaparoid, apixaban, rivaroxaban)
* Sample sent to the HUS Hematology Laboratory and analyzed for measurement of the anti-Xa activity of an anticoagulant as part of routine care

Exclusion Criteria:

* Patient with a basal lipidemic sample
* Sample of insufficient volume

Where it's running

• Laboratoire d'Hématologie - Unité d'Hémostase - CHU de Strasbourg - France
  Strasbourg, France Recruiting

Study contacts

• Study coordinator: Agathe HERB, PharmD
• Email: agathe.herb@chru-strasbourg.fr
• Phone: 33 3 88 12 75 53

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ion775 for high triglyceride levels: safety, tolerability, and how well it works

  A drug called ION775 is being tested to see if it can safely lower fasting triglycerides in adults with hypertriglyceridemia or severe hypertriglyceridemia who are already on standard lipid medicines.

  Recruiting at 17 sites Phase 2 Ionis Pharmaceuticals, Inc. · Lincoln, California and 17 other locations · NCT07604974

• Russian registry for people with very high triglycerides

  This registry collects health and genetic information from people in Russia who have very high triglycerides (≥10 mmol/L) to see what their causes, care, and outcomes look like.

  Recruiting at 6 sites Russian Cardiology Research and Production Center · Astrakhan and 5 other locations · NCT07508930

• CTX310 for refractory high triglycerides or LDL cholesterol

  This trial will test whether a single IV dose of CTX310 is safe and tolerated in adults whose high triglycerides or LDL cholesterol have not responded to available treatments.

  Recruiting at 16 sites Phase 1 CRISPR Therapeutics · Hialeah, Florida and 16 other locations · NCT07491172

• MAR001 for adults with high triglycerides and remnant cholesterol

  This trial will try the drug MAR001 to lower post-meal triglycerides and remnant cholesterol in adults with elevated triglyceride levels.

  Recruiting Phase 2 Marea Therapeutics · Chula Vista, California · NCT07199309

• JMT202 injections for adults with high triglycerides

  This will test whether repeated subcutaneous injections of JMT202 are safe and well tolerated in Chinese adults with high triglyceride levels.

  Recruiting Phase 1/2 Shanghai JMT-Bio Inc. · Beijing, Beijing Municipality · NCT07140809

• MAR001 in adults with high triglycerides and remnant cholesterol

  This study tests MAR001 against placebo to see if it lowers triglycerides and remnant cholesterol in adults with elevated levels.

  Recruiting at 21 sites Phase 2 Marea Therapeutics · Anniston, Alabama and 54 other locations · NCT07028749

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.