Condition
HGG clinical trials and research
As of November 12, 2026, Find a Trial lists 4 HGG clinical trials that are recruiting, at sites in 13 countries (most in Canada (2), United States (2), Australia (1)). By phase: Phase 1 (2), Early Phase 1 (1), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 13Countries
Newest HGG clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Taste of hope: testing NRG-103 safety and dosing for adults with high-grade glioma | Phase 1 | Shanghai and 2 other locations | Recruiting | Jul 17, 2026 |
| Fluorescent-labeled nivolumab (Nivo800) imaging for high-grade glioma surgery | Early Phase 1 | Nashville, Tennessee | Recruiting | Oct 7, 2025 |
| Focused ultrasound to open the blood-brain barrier in adults with high-grade glioma on chemotherapy | Phase 1 | Toronto, Ontario | Recruiting | Sep 17, 2025 |
| Assessing the effectiveness and safety of FORE8394 for cancer with BRAF alterations | Phase 2 | Beverly Hills, California and 69 other locations | Recruiting | Aug 17, 2022 |
All recruiting trials (4)
-
Taste of hope: testing NRG-103 safety and dosing for adults with high-grade glioma
This early-phase trial tests whether NRG-103 is safe and tolerable in adults with recurrent or progressive high-grade glioma and looks for early signs it might help.
-
Fluorescent-labeled nivolumab (Nivo800) imaging for high-grade glioma surgery
This trial tests whether a near-infrared fluorescent version of the immunotherapy drug nivolumab can be given before planned surgery to visualize drug distribution in adults with suspected high-grade glioma.
-
Focused ultrasound to open the blood-brain barrier in adults with high-grade glioma on chemotherapy
This trial tests whether focused ultrasound using the Next Generation Dome Helmet can safely open the blood-brain barrier in adults with glioblastoma who are receiving maintenance temozolomide chemotherapy.
-
Assessing the effectiveness and safety of FORE8394 for cancer with BRAF alterations
This study is testing a new cancer treatment called plixorafenib to see if it helps people with certain BRAF gene changes and advanced tumors feel better and live longer after other treatments have failed.
Related topics
Quick answers
How many HGG clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 13 countries. The most sites are in Canada (2 trials), United States (2 trials), Australia (1 trial), France (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 2, Early Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.