High-intensity interval training guided by cardiopulmonary exercise testing for HFpEF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates a CPET-guided high-intensity interval training approach for adults with HFpEF who have a sedentary lifestyle. The program uses cardiopulmonary exercise testing to tailor exercise intensity, with the aim of safely improving peak VO2 and metabolic and inflammatory profiles. Eligible participants are adults aged 35-70 with NYHA class II-III HFpEF and stable condition, without contraindications to CPET. The study is conducted across multiple Beijing-area hospitals under national and municipal health sponsorship. Outcomes focus on exercise capacity, safety, and related clinical parameters.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Men and women aged 35-70 years;
2. Physical inactivity / sedentary lifestyle defined as:

   Sedentary behavior: average daily sitting time \> 6 hours over the past 6 months; AND/OR Insufficient physical activity: average weekly moderate-intensity physical activity \< 150 minutes or vigorous-intensity physical activity \< 75 minutes as assessed by the International Physical Activity Questionnaire (IPAQ);
3. Patients with HFpEF at Stage 4 of CKM syndrome who have been clinically stable within the past month (New York Heart Association \[NYHA\] functional class II-III);
4. Willingness to improve health status through appropriate exercise.

Exclusion Criteria:

1. Presence of contraindications to cardiopulmonary exercise testing (CPET);
2. Positive findings on the exercise electrocardiogram (ECG) during CPET;
3. Diagnosis of psychiatric disorders;
4. Presence of movement disorders or lower extremity exercise-related injuries within the past 6 months;
5. Women who are pregnant, breastfeeding, or planning to become pregnant in the near future;
6. Other conditions deemed unsuitable for participation in this study by the investigators;
7. Refusal to sign the informed consent form.

Where it's running

• Peking University Third Hospital
  Beijing, China Recruiting
• Beijing Chao-Yang Hospital, Capital Medical University
  Beijing, China Not yet recruiting
• Beijing Hospital
  Beijing, China Not yet recruiting
• Beijing Xiaotangshan Hospital
  Beijing, China Not yet recruiting
• Beijing Zhongguancun Hospital
  Beijing, China Not yet recruiting
• Community Health Station of the Party School of the Central Committee of C.P.C
  Beijing, China Not yet recruiting

Study contacts

• Study coordinator: Yida Tang, MD,PhD
• Email: tangyida@bjmu.edu.cn
• Phone: 010-82265996

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.