Promoting exercise in adults with heart failure with preserved ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the effects of exercise coaching on adults with heart failure with preserved ejection fraction (HFpEF). Participants will be randomly assigned to one of three groups: one receiving in-person coaching, another using video conferencing for coaching, and a control group with access to exercise videos. Over 18 months, the study will assess exercise adherence, health status improvements, and changes in physical function and inflammatory markers. The study will also evaluate the cost-effectiveness and scalability of the intervention methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of heart failure with an ejection fraction greater than or equal to 50
* Echocardiogram in prior 24 months
* Stable pharmacologic therapy in the past 30 days
* Any of the following evidence to confirm HFpEF - Score\< 6 on Heavy Hypertensive Atrial Fibrillation, Pulmonary Hypertension, Elder, Filling Pressure algorithm, invasive hemodynamic evidence of HFpEF(i.e., elevated pulmonary wedge pressure), or a confirmed clinical diagnosis of HFpEF

Exclusion Criteria:

* Life-limiting illness precluding study completion
* Clinical evidence of decompensated heart failure
* Unstable angina or marked shortness of breath on exertion at less than 2 metabolic equivalents
* Myocardial infarction, coronary artery bypass graft, or biventricular pacemaker in prior 6 weeks
* Orthopedic or neuromuscular disorders preventing aerobic exercise
* Cardiopulmonary exercise test results that preclude safe exercise
* Unwilling/unable to complete pre-randomization procedures
* Pregnancy
* Implantable cardioverter defibrillator

Where it's running

• Henry Ford Health System
  Detroit, Michigan, United States Recruiting
• University of Nebraska Medical Center
  Omaha, Nebraska, United States Recruiting
• University of Virginia
  Charlottesville, Virginia, United States Not yet recruiting

Study contacts

• Principal investigator: Windy W Alonso, PhD — University of Virginia
• Study coordinator: Windy W Alonso, PhD
• Email: windy.alonso@unmc.edu
• Phone: 402-559-8342

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tamibarotene for HFpEF: see if this drug helps heart failure with preserved ejection fraction

  A 12-week trial tests whether tamibarotene can reduce NT-proBNP levels in adults with HFpEF compared with placebo.

  Recruiting Phase 2 Nagoya University · Nagoya, Aichi-ken and 3 other locations · NCT07855692

• High-intensity interval training guided by cardiopulmonary exercise testing for HFpEF

  This trial tests whether a personalized high-intensity interval training program, guided by CPET results, can help people with heart failure with preserved ejection fraction improve their fitness and symptoms.

  Recruiting Peking University Third Hospital · Beijing and 12 other locations · NCT07693049

• Finerenone in patients having TAVI with heart failure

  This study tests whether finerenone can help people with heart failure and preserved ejection fraction who are undergoing transcatheter aortic valve implantation.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Bengbu, Anhui and 60 other locations · NCT07575672

• Tiny ultrasound bubbles as an alternative to catheters for measuring pressures inside the heart

  This will test whether injecting tiny ultrasound bubbles can estimate heart filling pressures in people who are having a cardiac catheterisation.

  Recruiting King's College London · London · NCT07416279

• Tailored exercise training for adults with HFpEF

  This program will test remote, personalized exercise and lifestyle plans to see if they help adults with HFpEF or at risk of it improve how much they can exercise and their muscle health.

  Recruiting Phase 2/3 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07223242

• US benchmarking of heart and liver stiffness using shear wave ultrasound

  This project will test whether a new ultrasound device can measure heart and liver stiffness using shear wave velocity in people aged 60 or older with preserved or mildly reduced ejection fraction and left ventricular hypertrophy, with or without transthyretin amyloid cardiomyopathy, and in control subjects.

  Recruiting at 3 sites eMyosound SAS · Boston, Massachusetts and 2 other locations · NCT07215715

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.