Condition

HER2 clinical trials and research

• 9Clinical trials
• 1New in 30 days
• 9Countries

Newest HER2 clinical trials

All recruiting trials (9)

• 68Ga-XHER2 PET/CT imaging to see HER2 in solid tumors

  A noninvasive PET/CT imaging test using 68Ga-XHER2 is being tried to see if it reflects HER2 levels in solid tumors.

  Recruiting The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT07885436

• Trastuzumab plus serplulimab with chemotherapy for HER2-positive advanced biliary tract or urothelial cancer after prior therapy

  This study will test whether adding trastuzumab and serplulimab to chemotherapy helps people with HER2-positive unresectable or metastatic biliary tract cancer or urothelial carcinoma who have not responded to standard treatment.

  Recruiting Phase 2 China Medical University, China · Shenyang, Liaoning · NCT07506057

• Selective ERBB2 inhibitor CGT4255 for adults with ERBB2-altered advanced solid tumors

  This trial tests a targeted drug called CGT4255 in adults with advanced solid tumors that have ERBB2 (HER2) changes to see if it is safe and shows anti-tumor activity.

  Recruiting at 15 sites Phase 1 Cogent Biosciences, Inc. · Scottsdale, Arizona and 14 other locations · NCT07361562

• Tracking HER2 mutations and treatment patterns in advanced non-small cell lung cancer in Italy

  This project will see how people in Italy with advanced NSCLC and HER2 mutations are diagnosed and treated over a one-year follow-up period.

  Recruiting at 2 sites Gruppo Oncologico Italiano di Ricerca Clinica · Bari, BA and 21 other locations · NCT07356544

• Disitamab vedotin (RC48) plus carboplatin as first-line treatment for advanced HER2-positive ovarian, fallopian tube, or primary peritoneal cancer

  This trial will test whether combining disitamab vedotin (RC48) with carboplatin works and is safe as a first-line treatment for people with advanced HER2-positive ovarian, fallopian tube, or primary peritoneal cancer who have had initial debulking surgery.

  Recruiting Phase 2 Zhejiang Cancer Hospital · Zhejiang, Zhejiang · NCT07285941

• Radiology-based prediction of HER2 level and T‑DXd benefit in metastatic breast cancer

  This study tests whether patterns in CT or FDG‑PET images can show HER2 level and help predict response to trastuzumab deruxtecan for people with metastatic breast cancer.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan · NCT07030569

• PET imaging with [68Ga]Ga-ABY-025 to visualize HER2-positive and HER2-low tumors during HER2 therapy

  This trial will test whether a PET tracer called [68Ga]Ga-ABY-025 can better visualize tumors in adults with HER2-positive or HER2-low advanced cancers who are receiving HER2-targeted therapy.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT06828588

• Assessing a genomic classifier for HER2-positive early-stage breast cancer management

  This study is testing a new genetic tool to see if it can help predict how well women with early-stage HER2-positive breast cancer will do after treatment with certain therapies.

  Recruiting at 2 sites Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Brindisi and 1 other locations · NCT06762977

• Evaluating IAM1363 for HER2-related cancers

  This study is testing a new treatment called IAM1363 to see if it can help people with advanced cancers that have changes in the HER2 gene.

  Recruiting at 53 sites Phase 1 Iambic Therapeutics, Inc · La Jolla, California and 52 other locations · NCT06253871

Related topics

Quick answers

How many HER2 clinical trials are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Italy (4 trials), China (3 trials), United States (3 trials), France (1 trial), Ireland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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