Condition

Breast Cancer Early Stage Breast Cancer (Stage 1-3) clinical trials and research

• 26Clinical trials
• 1New in 30 days
• 12Countries

Newest Breast Cancer Early Stage Breast Cancer (Stage 1-3) clinical trials

All recruiting trials (26)

• Regular exercise to help women with early-stage breast cancer on hormone therapy

  This study tests whether a guided, 16-week exercise program improves quality of life and fitness for women with early-stage breast cancer who are starting adjuvant hormone therapy.

  Recruiting Fundación Investigación E Innovación Biomédica Hospital Universitario Infanta Sofia-Henares · San Sebastián de los Reyes, Madrid · NCT07893327

• Neoadjuvant Pyrotinib-to-pertuzumab for HER2-positive early breast cancer

  This trial tests whether a two-step neoadjuvant plan with Pyrotinib plus Trastuzumab and Docetaxel followed by Pertuzumab plus Trastuzumab and Docetaxel works better than four cycles of Pertuzumab plus Trastuzumab and Docetaxel in women with HER2-positive early- to locally advanced breast cancer.

  Recruiting Phase 3 Shanghai Jiao Tong University School of Medicine · Shanghai · NCT07797218

• Time‑restricted eating (8‑hour window) during chemotherapy for breast cancer: feasibility and acceptability

  This trial will test whether eating all daily food within an 8‑hour window is practical and acceptable for people starting chemotherapy for stage I–III breast cancer (and some stage IV with oncologist approval).

  Recruiting at 2 sites University of Illinois Chicago · Chicago, Illinois and 1 other locations · NCT07387445

• CPAP-assisted radiotherapy to lower heart and lung dose after breast-conserving surgery

  This tests whether wearing a CPAP breathing device during adjuvant radiotherapy can lower radiation exposure to the heart and lungs for women with early-stage (stage 1–3) breast cancer who had breast‑conserving surgery.

  Recruiting Phase 2/3 Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07373782

• Oncoliq blood test for early detection of breast cancer

  This project will test whether a blood-based miRNA panel (the Oncoliq Test) can detect early breast cancer in adults 40–70 by comparing newly diagnosed, untreated patients with cancer-free controls.

  Recruiting Oncoliq US Inc · Buenos Aires, Buenos Aires · NCT07331506

• Adjuvant CDK4/6 Inhibitors in Older Breast Cancer Patients: Geriatric Screening in Action

  This study tests whether using geriatric screening alongside adjuvant CDK4/6 inhibitors helps tailor therapy for adults aged 70 and older with early-stage breast cancer.

  Recruiting at 4 sites Region Jönköping County · Gävle and 4 other locations · NCT07273357

• ScarWork to treat long-term breast pain after surgery

  This trial will try ScarWork, a gentle manual scar therapy, to see if it reduces persistent breast pain in adults treated for early-stage breast cancer.

  Recruiting University College London Hospitals · London · NCT07206394

• Multimodal prehabilitation combining exercise, nutrition, and psychological support to improve chemotherapy response in early breast cancer

  This trial will try a combined program of exercise, nutrition, and psychological support during neoadjuvant chemotherapy to see if it improves tumor response in women with early-stage (I–III) breast cancer.

  Recruiting Hospital Clinic of Barcelona · Barcelona · NCT07107594

• HUAXI Hole 1–assisted reverse‑sequence endoscopic nipple‑sparing mastectomy with immediate implant reconstruction

  This project will test whether adding a 2‑mm 'HUAXI Hole 1' near the areola makes reverse‑sequence endoscopic nipple‑sparing mastectomy with direct‑to‑implant reconstruction faster, safer, and more cosmetic for women with early‑stage breast cancer or undergoing prophylactic mastectomy.

  Recruiting West China Hospital · Fuzhou, Fujian and 19 other locations · NCT06995118

• ctDNA-guided reduction of chemotherapy using dalpiciclib plus endocrine therapy in high-risk HR+/HER2- early breast cancer

  This trial tests whether giving the CDK4/6 drug dalpiciclib with endocrine therapy and using ctDNA results can let some women with early high-risk HR+/HER2- breast cancer skip or reduce chemotherapy.

  Recruiting Phase 2 Peking University People's Hospital · Beijing, Beijing Municipality · NCT06970912

• Judicious heart monitoring during HER2-targeted therapy for breast cancer

  This study tests a personalized heart-monitoring plan during HER2-positive breast cancer treatment to see if fewer, risk-tailored heart tests can safely replace routine quarterly imaging.

  Recruiting Women's College Hospital · Toronto, Ontario · NCT06930521

• SHR-A1811 and pertuzumab before surgery for HER2-positive breast cancer

  This study tests whether adding SHR-A1811 to pertuzumab, with or without albumin-paclitaxel, helps people with early HER2-positive breast cancer reach a pathologic complete response before surgery.

  Recruiting Phase 2 Henan Cancer Hospital · Zhengzhou, Henan · NCT06927180

• Fezolinetant for hot flashes in women with early-stage, hormone receptor–positive breast cancer on endocrine therapy

  This trial will test whether taking fezolinetant 45 mg daily can reduce moderate-to-severe hot flashes in women with early-stage, HR+ breast cancer who are on tamoxifen or aromatase inhibitors.

  Recruiting Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06917313

• Using a specific position during radiotherapy for left breast cancer patients

  This study is testing if a specific way of lying down during radiotherapy can help women with left breast cancer get better treatment while protecting their other organs.

  Recruiting at 2 sites Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong Provinse and 1 other locations · NCT06902051

• Nutrition intervention's effect on breast cancer patients' bioimpedance phase angle

  This study is testing if giving special nutritional supplements to women with early-stage breast cancer before and after surgery can help them recover better and improve their health.

  Recruiting University of Malaya · Petaling Jaya, Kuala Lumpur · NCT06890221

• Single vs. short-course radiation for partial breast cancer

  This trial tests whether a single-fraction partial breast irradiation is as effective and tolerable as the standard multi-fraction approach for women 40 and older with early-stage breast cancer.

  Recruiting British Columbia Cancer Agency · Prince George, British Columbia · NCT06885671

• Robotic-assisted nipple-sparing mastectomy for breast cancer

  This study is testing if robotic-assisted nipple-sparing mastectomy is a safe and effective option for women with early-stage breast cancer or those at high risk, compared to traditional surgery.

  Recruiting University Hospital A Coruña · A Coruña, Galicia · NCT06823414

• Adjuvant Treatment in Premenopausal Breast Cancer (Oncotype DX-Based)

  This study looks at how premenopausal women with early breast cancer who had the Oncotype DX test were treated after surgery and what their outcomes were.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, Antonella Palazzo and 1 other locations · NCT06807749

• Evaluating Circulating Tumor Cells in Breast Cancer Follow-up

  This study is testing a new way to track cancer cells in the blood of breast cancer patients to see how their condition changes during treatment.

  Recruiting ScreenCell · Neuilly-sur-Seine · NCT06807502

• Evaluating anticancer drug therapies for gynecologic and breast cancers

  This study is testing different cancer drug treatments to see how well they work and how well patients with breast and gynecologic cancers can tolerate them.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06800612

• Digital self-management support to improve quality of life during adjuvant hormonal therapy

  This trial tests whether a personalized mobile app plus usual care can help people with early hormone receptor–positive breast cancer have fewer endocrine therapy side effects and better quality of life.

  Recruiting Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Villejuif · NCT06781996

• Using question prompts to help breast cancer patients before chemotherapy

  This study is testing whether a list of questions can help breast cancer patients feel more informed and less anxious before starting chemotherapy.

  Recruiting Region Örebro County · Uppsala, Region Uppsala and 2 other locations · NCT06777420

• Assessing a genomic classifier for HER2-positive early-stage breast cancer management

  This study is testing a new genetic tool to see if it can help predict how well women with early-stage HER2-positive breast cancer will do after treatment with certain therapies.

  Recruiting at 2 sites Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Brindisi and 1 other locations · NCT06762977

• Partial breast reconstruction using chest wall perforator flaps

  This study looks at how well partial breast reconstruction using chest wall flaps works for women who have had surgery for early-stage breast cancer.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge, Cambridgeshire · NCT06728527

• Evaluating HER2DX's impact on treatment decisions for early stage HER2+ breast cancer

  This study is testing how the HER2DX test affects treatment choices for patients with early stage HER2+ breast cancer to see if it helps doctors feel more confident in their recommendations.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06723990

• Minimal Scar Mastectomy for Early Stage Breast Cancer

  This study tests a new surgery called minimal scar mastectomy for women with early-stage breast cancer who want to avoid reconstruction, to see if it can safely remove cancer while leaving a better appearance.

  Recruiting at 2 sites KK Women's and Children's Hospital · Singapore and 1 other locations · NCT06676761

Related topics

Quick answers

How many Breast Cancer Early Stage Breast Cancer (Stage 1-3) clinical trials are recruiting right now?

26, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in China (5 trials), Italy (4 trials), Spain (3 trials), United Kingdom (2 trials), Sweden (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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