Condition

Head and Neck Carcinoma clinical trials and research

• 19Clinical trials
• 4Countries

Newest Head and Neck Carcinoma clinical trials

All recruiting trials (19)

• Intraoperative Methadone for Postoperative Pain in Head and Neck Cancer Patients

  This trial tests whether giving methadone during surgery, in addition to standard fentanyl, helps control pain after head and neck cancer surgery more effectively than fentanyl alone.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07857655

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• Tongue-out positioning to lower mouth and swallowing side effects in head and neck cancer

  This trial will try a 'tongue-out' position during radiation to see if it lowers mouth sores, taste changes, and swallowing problems for people with oropharyngeal, laryngeal, or hypopharyngeal squamous cell carcinoma.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07227792

• Accelerator-based boron neutron capture therapy for recurrent head and neck cancer

  This trial will try accelerator-based boron neutron capture therapy with intravenous L‑Boronophenylalanine in adults whose head and neck cancer has returned after radiation.

  Recruiting Phase 1 Neutron Therapeutics, LLC · Helsinki · NCT07058116

• Using virtual reality to help improve mental health and pain in head and neck cancer patients and their caregivers

  This study is testing if a special virtual reality program can help improve mental health and reduce pain for people with head and neck cancer and their caregivers during treatment.

  Recruiting City of Hope Medical Center · Duarte, California · NCT06985784

• Financial Compass intervention for head and neck cancer patients facing financial hardship

  This study is testing a new program called Financial Compass to see if it can help head and neck cancer patients who are struggling with money feel more supported compared to regular care.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06896695

• Pre-surgery metronidazole and chlorhexidine to lower bacteria in oral cavity tumors

  This study will try a short course of the antibiotic metronidazole plus chlorhexidine mouthwash before surgery to see if it lowers bacteria inside tumors in adults with oral squamous cell carcinoma.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06627270

• Personalized radiation therapy for palliative treatment of head and neck cancer

  This study is testing a new way to give radiation therapy for people with head and neck cancer who can't have regular treatments, to see if it helps control tumors better and reduce side effects.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06572423

• Understanding head and neck cancer through detailed cellular analysis

  This study looks at the cells in head and neck cancer to see how they behave in patients with HPV-related throat cancer and their lymph nodes.

  Recruiting University of Southern California · Los Angeles, California · NCT06420219

• Identifying biomarkers for HPV-related oropharyngeal cancer

  This study is trying to find specific markers in blood and saliva that can help identify HPV-related throat cancer in patients who are already diagnosed with advanced stages of the disease.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06356272

• Italian registry for Head and Neck cancer patients

  This study is setting up a registry in Italy to collect important information about people with head and neck cancer to help improve research and treatment options.

  Recruiting at 7 sites Italian Head&Neck Society · Candiolo and 6 other locations · NCT06248944

• Evaluating skin reactions in head and neck cancer patients receiving proton therapy

  This study is testing a new way to reduce skin reactions in head and neck cancer patients getting proton therapy by using a special technique and personalized treatment plans.

  Recruiting Covenant Health Cancer Center · Knoxville, Tennessee · NCT06183268

• Reducing radiation and chemotherapy for head and neck cancer treatment

  This study is testing if giving less radiation and chemotherapy before surgery can still effectively treat certain head and neck cancers while reducing side effects for patients.

  Recruiting at 6 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 5 other locations · NCT05544136

• Combining radiation with experimental drugs for recurrent head and neck cancer

  This study is testing a new combination of experimental drugs and radiation therapy to see if it can safely help people with recurrent head and neck cancer.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT05526924

• Collecting blood samples to evaluate tests for early cancer detection

  This study is collecting blood and tissue samples from people with and without cancer to see if new tests can help detect cancer earlier.

  Recruiting at 619 sites Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 750 other locations · NCT05334069

• Genetic testing for cancer in diverse ethnic groups

  This study is testing how genetic testing can help cancer patients from different ethnic backgrounds understand their risks and improve their personalized care.

  Recruiting at 2 sites Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT04475640

• High-dose steroid therapy for late lower cranial neuropathy in oropharyngeal cancer survivors

  This study tests whether high-dose prednisone or methylprednisolone can improve symptoms of late radiation-related lower cranial nerve problems in adults who survived oropharyngeal cancer.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT04151082

• Treatment of solid tumors or lymphoma with VMD-928

  This study is testing a new oral medication called VMD-928 to see if it can help adults with advanced solid tumors or lymphoma that haven't improved with standard treatments.

  Recruiting at 13 sites Phase 1/2 VM Oncology, LLC · Santa Rosa, California and 12 other locations · NCT03556228

• Collecting data on side effects of proton therapy for cancer treatment

  This study is trying to learn about the side effects that cancer patients experience after receiving proton therapy to help improve future treatments.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT00991094

Related topics

Quick answers

How many Head and Neck Carcinoma clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (17 trials), Puerto Rico (1 trial), Finland (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 2, Phase 1: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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