Clinical trial Recruiting at 1 site Observational Ages 18 and up

Identifying blood and tissue markers for tumor hypoxia in head and neck and lung cancers

Official title: Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers

Run by Stanford University · NCT00568490 · Data updated 2026-11-12

This study is trying to find new blood and tissue markers that show low oxygen levels in tumors to help people with head and neck and lung cancers understand their condition better and improve treatment outcomes.

More Lung Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorStanford University
Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Stanford, California)
StatusRecruiting
StartedSeptember 1, 1998
Main results expectedJune 30, 2027
Study endsJune 30, 2027
Registry record updatedJuly 1, 2026
Trial IDNCT00568490 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients with histologically confirmed squamous cell carcinoma of the head and neck or non-small cell lung cancer.

Probably not a fit

Patients who do not have the specified types of cancer or who are unable to provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify and confirm new blood and tissue markers that indicate tumor hypoxia, a condition linked to increased tumor spread and resistance to treatment in head and neck and lung cancers. The research focuses on validating the prognostic significance of specific proteins, such as osteopontin, and monitoring their levels during therapy and follow-up. Additionally, the study seeks to establish a gene and protein signature associated with hypoxia in affected patients.

Why it matters

Potential benefit: If successful, this study could lead to improved prognostic tools and treatment strategies for patients with head and neck and lung cancers.

How similar studies have gone: Other studies have explored tumor hypoxia markers, but this specific approach may provide novel insights into prognostic indicators.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Histologically confirmed squamous cell carcinoma of the head and neck sites or non-small cell lung cancer, or relatives of patients with histologically confirmed squamous cell carcinoma of the head and neck.
* Able to sign a Stanford IRB approved consent form

Exclusion criteria:

* Refuse or unable to sign an IRB approved consent form.
* Refuse to be contacted in the future for follow up.

Where it's running

  • Stanford University School of Medicine
    Stanford, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.