How mutations in the TP53 gene affect cancer spread and immune response in head and neck cancers
Official title: Functional roles of GOF TP53 mutations in metastasis and immunosuppression of head and neck cancers
Funded at University of Tx Md Anderson Can Ctr · NIH-11034107 · Data updated 2026-11-12
This study is looking at certain changes in a gene called TP53 that are often found in head and neck cancers to see how they affect how the cancer grows and avoids the immune system, with the hope of finding new treatments that could work better for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 3, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $556,146 |
| NIH project number | 5R01DE030875-04 |
| Project ID | NIH-11034107 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma who have TP53 mutations.
✕Less likely to help
Patients with head and neck cancers that do not involve TP53 mutations may not benefit from this research.
What this research studies
This research investigates the role of specific mutations in the TP53 gene that are commonly found in head and neck cancers. It aims to understand how these mutations contribute to cancer cell behavior, including their ability to spread and evade the immune system. By focusing on the mechanisms of these mutations, the research seeks to identify new treatment strategies that could target these processes. Patients may benefit from insights that could lead to more effective therapies tailored to their specific cancer mutations.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with head and neck cancers.
How similar studies have gone: Previous research has shown promising results in targeting mutations in cancer genes, suggesting that this approach could be effective.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Myers, Jeffrey Nicholas — University of Tx Md Anderson Can Ctr
- Study coordinator: Myers, Jeffrey Nicholas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.