Improving radiation therapy for early stage breast cancer
Evaluation of image-guided, conformal, high-dose intraoperative radiation therapy (Precision Breast IORT) for early stage breast cancer
This study is testing a new way to give radiation therapy during breast cancer surgery that uses advanced imaging to better target the treatment, and it's for women with early-stage breast cancer who want to see if this method works better than the usual approach.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10463616 on NIH RePORTER |
What this research studies
This research focuses on enhancing intraoperative radiation therapy (IORT) for early stage breast cancer by utilizing advanced imaging techniques and high-dose brachytherapy. The study aims to develop a new method called Precision Breast IORT (PB-IORT), which allows for more accurate targeting of breast tissue during treatment. By comparing the effectiveness and costs of PB-IORT to traditional methods, the research seeks to provide better outcomes for patients. Participants will be involved in a multi-center Phase II trial assessing both clinical and immune responses to this innovative therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early stage breast cancer who are considering radiation therapy.
Not a fit: Patients with advanced breast cancer or those who have already undergone extensive treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for early stage breast cancer, potentially reducing recurrence rates.
How similar studies have performed: Previous studies have shown promise in using advanced imaging and high-dose radiation techniques, suggesting that this approach could lead to significant improvements in treatment outcomes.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Showalter, Shayna Lefrak — University of Virginia
- Study coordinator: Showalter, Shayna Lefrak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.