Using Negative Pressure Wound Therapy for Healing Diabetic Foot Wounds

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of Negative Pressure Wound Therapy (NPWT) in combination with dermal substitutes for treating diabetic foot ulcers. Given the high rates of diabetes-related amputations in Singapore, the study aims to improve wound healing and reduce infection risks associated with these ulcers. Participants will receive NPWT and may undergo delayed primary closure with a local flap if necessary. The study focuses on patients who have experienced toe ray amputations and have adequate blood flow to the affected area.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 21-100
* First or last toe ray amputation
* Adequate perfusion (either \>50% stenosis on duplex ultrasound or undergone successful revascularization with \<30% residual stenosis)

Exclusion Criteria:

* Amputations not at first or last toe
* Venous ulcers
* Heel ulcers
* Osteomyelitis
* Active Infection
* Patients on imunosuppressant
* Patients with known allergy to fish
* Patients unable to give informed consent.

Where it's running

• Singapore General Hospital
  Singapore, Singapore Recruiting
• Sengkang General Hospital
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Jack Kian Ch'ng — Singapore General Hospital
• Study coordinator: Charyl Yap, B.Sc
• Email: charyl.yap.j.q@sgh.com.sg
• Phone: +65 6576 7986

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.