Evaluating a new bone graft for spine surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical study aims to assess the safety and effectiveness of NB1 Bone Graft in patients with degenerative disc disease who are undergoing transforaminal lumbar interbody fusion. Approximately 30 participants will be enrolled across three clinical sites, where they will undergo x-rays and CT scans during baseline and follow-up assessments. The study will also collect data on adverse events and immunology, as well as patient-reported outcomes related to quality of life, pain, and function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Documented diagnosis of degenerative disc disease
* Up to Grade I spondylolisthesis
* Eligible to undergo a single vertebral level spine fusion (L2 to S1)

Exclusion Criteria:

* Previous spinal instrumentation or previous interbody fusion procedure at the involved level
* Grade II or greater spondylolisthesis
* Systemic or local infection at the site of surgery

Where it's running

• Monash Medical Center
  Clayton, Victoria, Australia Recruiting
• St Vincent Melbourne
  Fitzroy, Australia Recruiting

Study contacts

• Principal investigator: Jeremy Kam, MD — Monash Health
• Study coordinator: Brent Atkinson, PhD
• Email: atkinsonbrent520@gmail.com
• Phone: 13035507866

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing two bone grafts for spine surgery outcomes

  This study is testing whether two different bone grafts can help patients with spine surgery heal better and achieve solid bone fusion.

  Recruiting Lindenhofgruppe AG · Bern · NCT05238740

• PMCF look at METROSAN spinal systems and BONEGRAFT materials in adults after spine surgery

  This PMCF study tests the safety and performance of METROSAN Titania spinal systems and Bonegraft materials in adults undergoing spinal fusion or stabilization in routine practice.

  Recruiting Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co. · Izmir and 2 other locations · NCT07615491

• Bone marrow concentrate injection added to lumbar microdiscectomy

  This trial tests whether adding a bone marrow aspirate concentrate injection during lumbar microdiscectomy helps adults recover better than surgery alone.

  Recruiting Weill Medical College of Cornell University · Manhattan, New York · NCT07386548

• IDCT (Intradiscal Cell Therapy) for single-level mild-to-moderate lumbar degenerative disc disease

  This will test whether injecting IDCT (rebonuputemcel) into one degenerating lower-back disc can reduce chronic low back pain in adults with mild-to-moderate lumbar degenerative disc disease.

  Recruiting at 30 sites Phase 3 DiscGenics, Inc. · Birmingham, Alabama and 30 other locations · NCT07254806

• Novosis Putty used with transforaminal lumbar interbody fusion for lumbar degenerative disc disease

  The trial will test whether using Novosis Putty during transforaminal lumbar interbody fusion helps adults with lumbar degenerative disc disease heal better compared with standard care.

  Recruiting at 8 sites Phase 3 CGBio Inc. · Little Rock, Arkansas and 9 other locations · NCT07017634

• Orthosis and Exercise for Grade 1–2 Spondylolisthesis

  This study tests whether stabilization exercise, conventional exercise, or wearing an orthosis can improve pain, physical function, and quality of life in adults with mild spondylolisthesis.

  Recruiting Medipol University · Istanbul, Istanbul · NCT06989138

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.