Using modified stem cell particles to treat degenerative disc disease

Who could benefit from this research

What this research studies

This research investigates the use of extracellular vesicles (EVs) produced by genetically modified mesenchymal stem cells (MSCs) as a potential therapy for degenerative disc disease (DDD), a common cause of low back pain. The approach focuses on enhancing the regenerative properties of these EVs to combat inflammation and promote healing in the intervertebral discs. By modifying MSCs to increase the production of specific proteins, the study aims to improve the therapeutic effects of the EVs without the complications associated with direct cell therapies. Patients may benefit from a novel treatment option that could alleviate pain and improve mobility.

Why it matters

Where this research is happening

• Rochester Institute of Technology
  Rochester, United States Active

Researchers

• Principal investigator: Wuertz-Kozak, Karin — Rochester Institute of Technology
• Study coordinator: Wuertz-Kozak, Karin

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.