Impact of pre-existing degeneration on outcomes after lumbar fusion surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study enrolls patients requiring posterior lumbar interbody fusion (PLIF) for degenerative lumbar conditions. It focuses on the influence of pre-existing adjacent segment degeneration factors, such as degenerated discs and spinal canal stenosis, on long-term postoperative outcomes. The study aims to identify how these factors affect the risk of adjacent segment disease and the overall quality of life post-surgery. By analyzing these pre-existing conditions, the research seeks to improve surgical strategies and patient management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A clear diagnosis of lumbar spinal stenosis, and surgical level of L4- S1 (The levels to be operated on were decided by matching the clinical symptomatology with the radiological findings of the spinal levels that needed decompression);
* Failed at least eight weeks conservative treatment;

Exclusion Criteria:

* Unstable factors (slip, rotation, lateral bending, etc.) in adjacent segment L3/4;
* Preoperative sagittal and coronal imbalance of the spine;
* Lumbar infection and/or tumor diseases;
* A previous history of lumbar fusion surgery.

Where it's running

• Peking University Third Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Wei Shi Li, Dr. — Peking University Third Hospital
• Study coordinator: Zhuo Ran Sun, Dr.
• Email: puh3_szr@outlook.com
• Phone: +8618610292513

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.