Improving MRI accuracy for early-stage rectal cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to enhance the accuracy of MRI assessments for early-stage rectal cancer and significant rectal polyps, thereby reducing the need for major surgical interventions. By training radiologists in a new MRI reading method called PRESERVE, the study seeks to increase the identification rate of early rectal cancers from 30% to 89%. The goal is to enable more patients to undergo local excision procedures that preserve bowel function and quality of life, rather than facing unnecessary major surgeries. The study involves collaboration with multiple healthcare institutions to implement this improved staging system.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Have a rectal tumour or suspected tumour less than or equal to T3b on MRI stage or pT2 or less after excision, or 20mm or more on endoscopy with suspicion of malignancy
2. Be aged 16 years or over

Exclusion Criteria:

1. Have metastatic disease at time of initial staging
2. Have a biopsy-proven rectal malignancy which is not adenocarcinoma
3. Are contraindicated for MRI

Where it's running

• Buckinghamshire Healthcare Nhs Trust
  Amersham, Buckinghamshire, United Kingdom Recruiting
• Royal Berkshire Hospital
  Reading, Berkshire, United Kingdom Not yet recruiting
• University College London Hospitals Nhs Foundation Trust
  London, Greater London, United Kingdom Not yet recruiting
• King'S College Hospital Nhs Foundation Trust
  London, Greater London, United Kingdom Not yet recruiting
• West Middlesex Hospital
  London, Greater London, United Kingdom Not yet recruiting
• Imperial College Healthcare Nhs Trus
  London, Greater London, United Kingdom Not yet recruiting

Study contacts

• Principal investigator: Gina Brown, MD — Imperial College London
• Study coordinator: Caroline Martin
• Email: c.martin1@imperial.ac.uk
• Phone: +44 (0) 7749 655 817

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.