Observational study on early-onset colorectal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients diagnosed with colorectal cancer between the ages of 18 and 40. It aims to explore the biology of very early-onset colorectal cancer (vEO-CRC) through both retrospective and prospective data collection across multiple centers in Italy. The study will analyze clinicopathological features, survival data, and assess colibactin presence in tumor samples using advanced genomic techniques. Additionally, a subset of patients will undergo proteomic assessment to identify potential new therapeutic targets.

Why it matters

Who can join: the full rules

1. Patients with diagnosis of colorectal cancer (vEO-CRC: 18-40 years of age), or SO-CRC diagnosed later than age 60;
2. Informed consent signature from alivepatient;
3. Availability of formalin-fixed paraffin embedded (FFPE) tumor samples (5 FFPE 4uM thick slides and 10 FFPE 10 uM thick slides) and/or fresh tumor tissue retrieved from a biopsy or surgical procedure performed as per clinical standard of care.

Where it's running

• ASST Grande Ospedale Metropolitano Niguarda
  Milan, Milano, Italy Recruiting

Study contacts

• Study coordinator: Salvatore Siena, MD
• Email: salvatore.siena@ospedaleniguarda.it
• Phone: +39 02 6444

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.