Investigating how fatty fibrosis affects severe limb ischemia
Official title: The role of fatty fibrosis in chronic limb threatening ischemia pathobiology
Funded at University of Florida · NIH-11002309 · Data updated 2026-11-12
This study is looking at how fatty fibrosis affects people with chronic limb threatening ischemia (CLTI), a condition that causes poor blood flow and can lead to severe pain or even amputation, to find new ways to improve blood flow and muscle function in those struggling with this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $624,596 |
| NIH project number | 5R01HL171050-02 |
| Project ID | NIH-11002309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic limb threatening ischemia who may be experiencing severe pain or are at risk of limb amputation.
✕Less likely to help
Patients who do not have chronic limb threatening ischemia or those with other unrelated conditions may not benefit from this research.
What this research studies
This research focuses on chronic limb threatening ischemia (CLTI), a serious condition resulting from poor blood flow that can lead to severe pain and limb amputation. The study examines how fatty fibrosis, which is the replacement of muscle with fat and scar tissue, impacts the condition. By using advanced mouse models and patient tissue samples, researchers aim to understand the cellular mechanisms behind this process and explore potential therapeutic strategies that could improve blood flow and muscle function in affected limbs.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce the need for amputations in patients with CLTI.
How similar studies have gone: Other research has shown promising results in manipulating cellular pathways similar to Hedgehog signaling, indicating potential for success in this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Ryan, Terence E — University of Florida
- Study coordinator: Ryan, Terence E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.