Tailored treatment paths for people with severe limb-threatening leg artery disease
Official title: Tailored Treatment Strategies for Patients with Chronic Limb Threatening Ischemia
Funded at Univ of North Carolina Chapel Hill · NIH-11393306 · Data updated 2026-11-12
This grant aims to use advanced analytics to create personalized treatment sequences for adults with chronic limb-threatening ischemia to improve survival and limb preservation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 15, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $661,467 |
| NIH project number | 5R01HL179230-02 |
| Project ID | NIH-11393306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic limb-threatening ischemia who have completed or are eligible for revascularization strategies and are under ongoing vascular care.
✕Less likely to help
Patients without CLTI or those not undergoing sequential treatment planning may not benefit.
What this research studies
If funded, researchers will analyze data from people with chronic limb-threatening ischemia to understand how medical care, wound care, and vascular procedures come together over time. They will apply machine learning to identify which treatment sequences work best for different patients, taking into account medical factors and social circumstances. The goal is to develop clear, personalized pathways that clinicians can follow to maximize limb preservation and survival. The work builds on prior trials and uses existing data to refine treatment decisions for people living with this serious condition.
Why it matters
Potential benefit: Better, more personalized treatment plans could improve survival and save limbs for people with CLTI.
How similar studies have gone: Previous trials like BEST-CLI showed which revascularization method works best in some cases; this study extends that work with data-driven sequencing.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Mcginigle, Katharine L — Univ of North Carolina Chapel Hill
- Study coordinator: Mcginigle, Katharine L
Related research
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Improving Chronic Limb-Threatening Ischemia in the U.S.
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This study is testing a new way to help veterans with chronic limb threatening ischemia, a serious condition that can lead to losing a limb, by using special cells to improve blood flow and heal damaged blood vessels.
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Investigating how fatty fibrosis affects severe limb ischemia
This study is looking at how fatty fibrosis affects people with chronic limb threatening ischemia (CLTI), a condition that causes poor blood flow and can lead to severe pain or even amputation, to find new ways to improve blood flow and muscle function in those struggling with this issue.
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Using machine learning to predict disease progression and survival in patients with severe limb ischemia.
This study is working on a smart system that helps doctors understand how serious chronic limb-threatening ischemia (CLTI) is for patients and how it changes over time, so they can give the best treatment possible and improve health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.