Improving Chronic Limb-Threatening Ischemia in the U.S.
Official title: Improving Chronic Limb Threatening Ischemia Across the US
Funded at University of Alabama at Birmingham · NIH-11294860 · Data updated 2026-11-12
A nationwide study aims to understand why some people with severe leg artery disease progress to limb-threatening conditions and amputation, with an emphasis on Black adults and other communities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | June 22, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $735,327 |
| NIH project number | 1R01HL178865-01A1 |
| Project ID | NIH-11294860 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with PAD or at risk for CLTI, especially Black adults and residents of diverse geographic areas.
✕Less likely to help
Individuals without PAD risk factors or not residing in communities studied may not experience direct benefit.
What this research studies
This project uses data from a long-term community cohort to explore how social factors and health disparities influence risk of CLTI and amputation. It will look at how measures like the ankle-brachial index relate to future limb events in diverse populations. The goal is to identify population and individual factors that could guide prevention and reduce disparities in outcomes for people with PAD. Researchers will analyze health records, survey data, and regional information to pinpoint where interventions could help most.
Why it matters
Potential benefit: If successful, findings could lead to earlier identification of high-risk individuals and more equitable prevention and treatment strategies for CLTI.
How similar studies have gone: Prior work has linked social determinants to vascular outcomes, with ongoing efforts building on these associations.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Jackson, Elizabeth a. — University of Alabama at Birmingham
- Study coordinator: Jackson, Elizabeth a.
Related research
Other NIH-funded projects on the same topics.
-
Proteomics and precision treatment for severe limb-threatening PAD (CLTI)
A patient-facing look at using blood protein data to predict outcomes and guide safer, more effective treatment for people with the most severe peripheral artery disease.
-
Tailored treatment paths for people with severe limb-threatening leg artery disease
This grant aims to use advanced analytics to create personalized treatment sequences for adults with chronic limb-threatening ischemia to improve survival and limb preservation.
-
Fatty scarring in severe leg ischemia
Researchers are seeing whether changing a cell signal called Hedgehog can reduce fat and scar tissue in calf muscles and help people with severe poor blood flow to the leg regain better blood flow and muscle function.
-
Using stem cells to improve blood flow in patients with severe leg ischemia
This study is testing a new way to help veterans with chronic limb threatening ischemia, a serious condition that can lead to losing a limb, by using special cells to improve blood flow and heal damaged blood vessels.
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Investigating how fatty fibrosis affects severe limb ischemia
This study is looking at how fatty fibrosis affects people with chronic limb threatening ischemia (CLTI), a condition that causes poor blood flow and can lead to severe pain or even amputation, to find new ways to improve blood flow and muscle function in those struggling with this issue.
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Using machine learning to predict disease progression and survival in patients with severe limb ischemia.
This study is working on a smart system that helps doctors understand how serious chronic limb-threatening ischemia (CLTI) is for patients and how it changes over time, so they can give the best treatment possible and improve health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.