Combining TGF-β and PDL-1 inhibition with chemoradiation for esophageal cancer

TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY

This study is testing if a new treatment combining a drug called bintrafusp alfa with standard chemotherapy and radiation can be safely given to patients with advanced esophageal cancer that can't be surgically removed.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 49 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (Academic / other)
• Drugs / interventions: chemotherapy, radiation, prednisone
• Locations: 1 site (Amsterdam)
• Trial ID: NCT04481256 on ClinicalTrials.gov

What this trial studies

This study evaluates the feasibility of using bintrafusp alfa, a dual inhibitor of TGF-β and PDL-1, in conjunction with definitive chemoradiation therapy for patients with squamous cell carcinoma of the esophagus or gastroesophageal junction. Participants will receive a regimen of paclitaxel, carboplatin, and radiation, with bintrafusp alfa administered every three weeks. The study aims to determine if this combination can be safely delivered and tolerated by patients with advanced disease that is not amenable to surgical resection.

Who should consider this trial

Good fit: Ideal candidates include patients with histologically confirmed squamous cell carcinoma of the esophagus or gastroesophageal junction who are not eligible for surgery.

Not a fit: Patients with distant metastasis beyond supraclavicular lymph nodes or those with tumors that are fully resectable may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could improve treatment outcomes for patients with advanced esophageal cancer by enhancing the effectiveness of chemoradiation.

How similar studies have performed: While the combination of TGF-β and PDL-1 inhibition is a novel approach, similar studies targeting these pathways in other cancers have shown promising results.

Eligibility criteria

Inclusion Criteria:

* Histologically proven squamous cell carcinoma of the esophagus or gastro esophageal junction.
* Surgically irresectable (T1-T4a, N0 or N+, M0), as determined by Endoscopic Ultra Sound (EUS), PET scan and diagnostic CT scan of neck, thorax and abdomen. Patients with M1 disease solely on the basis of supraclavicular metastasis are eligible. Patients with resectable tumors refusing radical surgery are eligible.
* Locoregional recurrences without distant metastasis after surgery alone or endoscopical resection
* Locoregional recurrences without distant metastasis after neoadjuvant chemoradiation + resection or definitive chemoradiation outside the previously irradiated area, provided that full dose of radiation can safely be delivered.
* Tumors that cannot be passed with an endoscope for endoscopic ultrasound are eligible if all other criteria are fulfilled.
* If the tumor extends below the gastroesophageal (GE) junction into the proximal stomach, the bulk of the tumor must involve the esophagus or GE junction.
* Age ≥ 18.
* ECOG performance status 0-2 (cf. Appendix A).
* Adequate hematological, renal and hepatic functions defined as:

  * Neutrophils ≥ 1.5 x 109/L
  * Platelets ≥ 100 x 109/L
  * Hemoglobin ≥ 5.6 mmol
  * Total bilirubin ≤ 1.5 x upper normal limit
  * ASAT and ALAT ≤ 1.5 x upper normal limit, Alkaline Phosphatase ≤ 2.5 x upper normal limit.
  * PT (INR) ≤ 1.5 x upper normal limit and aPTT ≤ 1.5 x upper normal limit.
  * Creatinine clearance (Cockroft) \> 60 ml/min
* Written, voluntary informed consent
* Patients must be accessible to management and follow-up in the treatment center

Exclusion Criteria:

* Past or current history of malignancy other than entry diagnosis interfering with prognosis of esophageal cancer.
* Patient with tracheo-esophageal fistula or extension into the mucosal layer of the trachea, highly at risk to develop fistula. Thus, tumor extension to the trachea is allowed, but not through the trachea.
* Patients with pathological lymph nodes at both supraclavicular and truncus coeliacus level.
* Pregnancy (positive serum pregnancy test), planning to become pregnant, and lactation.
* Patient (male or female) in the reproductive age is not willing to use highly effective methods of contraception (per institutional standard) during treatment and for 6 months (male or female) after the end of treatment.
* Previous chemotherapy, radiation and/or treatment with checkpoint inhibitors for the currently present esophageal tumor.
* Previous chemotherapy and/or treatment with targeted agents and/or checkpoint inhibitors for other forms of cancer within the last six months.
* Previous radiation to the mediastinum precluding full dose radiation of the currently present esophageal tumor.
* Persisting grade \>1 NCI CTCAE 5.0 toxicity (except alopecia and vitiligo) related to prior therapy; however, grade ≤2 sensory neuropathy is acceptable.
* Presence of an esophageal stent.
* History of bleeding diathesis or major bleeding event (grade ≥ 2) in the month prior to first dose of trial treatment.
* Current use of direct oral anticoagulants or coumarins.
* Clinically significant cardiovascular disease precluding safe treatment with chemoradiation.
* Evidence of pulmonary fibrosis and/or clinically significant impairment of lung function precluding safe treatment with chemoradiation. In case of doubt about pulmonary function, a lung function test should be performed and, in case of abnormalities, discussed with the principle investigator.
* Serious underlying medical condition which would impair the ability of the patient to receive the planned treatment, including prior allergic reactions to drugs containing cremophor, such as teniposide or cyclosporine.
* Mental status that would prohibit the understanding and giving of informed consent.
* Inadequate caloric- and/or fluid intake despite consultation of a dietician and/or tube feeding.
* Has an active autoimmune disease that has required systemic treatment in past 2 years (i.e. with use of disease modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (e.g., thyroxine for patients with a history of autoimmune-related hypothyroidism, insulin for patients with type 1 diabetes mellitus, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment. Patients with vitiligo with dermatological manifestations only are eligible to enter the study.
* A diagnosis of immunodeficiency or is receiving systemic steroid therapy (\>10 mg/day prednisone or equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment.
* Diagnosis of HIV unless stable on antiretroviral therapy for at least 4 weeks, no evidence of multi-drug resistance, viral load of \< 400 copies/ml and CD4+ T-cells ≥ 350 cells/µl.
* Active HBV/HCV. Participants on a stable dose of antiviral therapy with HBV/HCV viral load below the limit of quantification are eligible.
* Evidence of interstitial lung disease or active, non-infectious pneumonitis.
* An active infection requiring systemic therapy, which has not resolved 3 days (simple infection such as cystitis) to 7 days (severe infection such as pyelonephritis) prior to the first dose of trial treatment.
* Administration of a live vaccine within 30 days prior to the first dose of trial treatment. Seasonal flu vaccines that do not contain a live virus are permitted.
* Patients with prior allogeneic stem cell or solid organ transplantation.

Where this trial is running

Amsterdam

• Academic Medical Center, Medical Oncology — Amsterdam, Netherlands (Recruiting)

Study contacts

• Principal investigator: Hanneke WM van Laarhoven, MD,PhD — Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Study coordinator: Linde M Veen, MD

Conditions Carcinoma, Squamous Cell; Oesophageal Cancer; Definitive chemoradiation; TGF-beta inhibition; PDL-1 ihibition; feasability