Condition

Breast Cancer (Locally Advanced or Metastatic) clinical trials and research

• 9Clinical trials
• 1New in 30 days
• 4Countries

Newest Breast Cancer (Locally Advanced or Metastatic) clinical trials

All recruiting trials (9)

• ESR1 Mutations in Metastatic Hormone Receptor‑Positive Breast Cancer in Greece

  This study tests how common ESR1 mutations are in Greek patients with advanced hormone receptor–positive, HER2‑negative breast cancer and looks at how those mutations relate to disease features and real-world treatment patterns.

  Recruiting Hellenic Cooperative Oncology Group · Athens · NCT07899463

• Intratumoral H101 with immune checkpoint inhibitors for advanced breast cancer

  This real-world, single-center study tests whether injecting H101 into tumors plus immune checkpoint inhibitors can help patients with advanced breast cancer who have limited options.

  Recruiting Foshan Fosun Chancheng Hospital · Guangdong, Foshan · NCT07850869

• Testing different doses of BL0175 injections in postmenopausal HR-positive, HER2-negative breast cancer

  This study tests different BL0175 doses to see which works best for postmenopausal patients with HR-positive, HER2-negative locally advanced or metastatic breast cancer.

  Recruiting Phase 2 Shanghai Best-Link Bioscience, LLC · Shanghai, Shanghai Municipality · NCT07658183

• INV-6452 in adults with HR+/HER2- advanced/metastatic breast cancer or other solid tumors

  This study tests INV-6452 to see if it is safe and tolerable and to get a first look at its activity in adults with HR+/HER2- advanced breast cancer or other advanced solid tumors.

  Recruiting Phase 1/2 Shenzhen Ionova Life Sciences Co., Ltd. · Shanghai, Shanghai Municipality · NCT07612891

• Phone app for remote symptom monitoring and management during cancer treatment

  This trial will test whether the ASSIST smartphone app can be used and is liked by people with breast cancer, colorectal cancer, or lymphoma who are starting systemic treatment.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07553572

• Dual-target CAR-NK therapy for advanced HER2-positive and triple-negative breast cancer

  This test gives a personalized dual-target CAR-NK cell infusion after short-course chemo to see if it is safe and can shrink tumors in adults with advanced HER2-positive or triple-negative breast cancer whose tumors express HER2, MUC1, or ROR1.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07486089

• Skin tattoo marks (and optional clips) to guide breast-conserving surgery before chemotherapy

  This study will test whether marking palpable tumor edges with sterile skin tattoos, with or without small radiopaque clips, before neoadjuvant chemotherapy helps surgeons perform breast-conserving surgery in adults with T2–T3 breast cancer.

  Recruiting All India Institute of Medical Sciences, Bhubaneswar · Bhubaneswar, Odisha · NCT07478900

• EBNK-001 allogeneic NK cell therapy with low-dose IL-15, with or without pembrolizumab, for advanced solid tumors

  This treatment tests an off-the-shelf NK cell product (EBNK-001) given with low-dose IL-15, either alone or with pembrolizumab, in adults with advanced or metastatic solid tumors who have exhausted standard options.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT07410676

• SH009 injection for advanced solid tumors

  This trial will test whether SH009 injections are safe and can shrink or slow advanced solid tumors in adults with cancers such as liver, lung, breast, head and neck, and esophageal cancer who have progressed after prior treatment.

  Recruiting Phase 1 Nanjing Sanhome Pharmaceutical, Co., Ltd. · Shanghai · NCT07390838

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Quick answers

How many Breast Cancer (Locally Advanced or Metastatic) clinical trials are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (6 trials), United States (1 trial), Greece (1 trial), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 3, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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