Condition

Brain Disease clinical trials and research

• 10Clinical trials
• 8NIH research projects
• 3Countries

Newest Brain Disease clinical trials

All recruiting trials (10)

• PEARL: Rehabilitation and recovery after atrial fibrillation-related ischemic stroke

  This project will see if adults with atrial fibrillation-related ischemic stroke have different rehabilitation needs and whether higher-intensity inpatient therapy (3–5 sessions/day) leads to better functional recovery at six months than moderate-intensity care (1 session/day).

  Recruiting Parc de Salut Mar · Barcelona · NCT07253974

• Axial and cognitive symptoms and biomarkers in brain‑first versus body‑first Parkinson's disease

  This project will test whether clinical exams, sleep testing, heart and brain scans, and blood/CSF biomarkers can distinguish brain‑first from body‑first early Parkinson's patients and predict worsening of balance and thinking problems.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia · NCT07187843

• Motor thalamus deep brain stimulation to improve movement and speech

  This trial will test turning deep brain stimulation on and off in adults who already have DBS implants for movement disorders to see if stimulation improves arm and hand movement, facial movement, speech, and swallowing.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07056348

• Understanding how social factors affect cognitive function after stroke

  This study looks at how social factors, like support from family and friends, affect how well people recover mentally after having a stroke.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06615973

• Using deep brain stimulation to improve speech and arm function after stroke

  This study is testing if deep brain stimulation can help improve hand movement and speech in people who have had a stroke.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06303869

• Effects of a medication on blood vessel function and organ injury in heart surgery patients

  This study tests if a medication called vericiguat can improve blood vessel function and reduce kidney and brain injury in patients having heart surgery.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05812755

• Testing a new brain PET insert for better imaging with MRI

  This study is testing a new brain imaging tool that combines PET and MRI scans to see if it can improve how we look at brain diseases in people.

  Recruiting Stanford University · Palo Alto, California · NCT04383808

• Exploring Brain Connections for Arm Movement After Stroke

  This study is testing how different parts of the brain work together to control arm movement before and after a stroke, to see if new stimulation methods can help stroke patients regain better use of their arms.

  Recruiting VA Office of Research and Development · Pittsburgh, Pennsylvania · NCT04286516

• Understanding how infections and inflammation affect the brain and nervous system

  This study is trying to understand how infections and inflammation impact the brain and nervous system by looking at samples and health information from people with these conditions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02435810

• Understanding the natural history of stroke and its causes

  This study is trying to gather detailed information from people who have had a stroke or a mini-stroke to better understand how these conditions develop and what causes them.

  Recruiting at 3 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT00009243

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Homeotic changes in human eye and brain disease linked to Xq27 insertions

  Aims to understand why certain DNA insertions at the Xq27 site near SOX3 cause eye and brain disorders by studying patient cells and mouse models.

  NIH research University of California at Davis · Davis, United States · NIH-11383526

• How a common virus can cause deadly brain disease (PML)

  This work looks at where the JC virus hides and how it gets into the brain in people with weakened immune systems who can develop PML.

  NIH research Brown University · Providence, United States · NIH-11369625

• Shared neuroscience platform to advance brain research and training

  A national hub at Stanford provides shared brain-research tools, models, and imaging methods to help scientists study brain development, disease, and behavior using 3D cultures, organoids, and viral vectors.

  NIH research Stanford University · Stanford, United States · NIH-11355352

• Understanding how mutations in brain cells contribute to brain diseases.

  This study is looking at how tiny genetic changes in different brain cells might contribute to conditions like focal cortical dysplasia, which can cause severe epilepsy and other brain-related issues, to help us understand how these changes affect brain health and function.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11166304

• An X‑chromosome genetic hotspot linked to inherited eye and brain disorders

  This project looks at how DNA insertions near the SOX3 gene on the X chromosome cause several inherited eye and brain conditions by changing which cells genes turn into, using patient cells and lab models.

  NIH research University of California at Davis · Davis, United States · NIH-11128696

• A platform for advancing brain research and training

  This study is all about bringing together tools and training to help researchers better understand how the brain develops and what happens when it gets sick, so if you're a scientist interested in brain research, this is a great chance to learn new techniques and work with others in the field!

  NIH research Stanford University · Stanford, United States · NIH-11088239

• Investigating genetic causes of eye and brain diseases

  This study is looking at how certain genetic changes can cause eye and brain disorders like BASR syndrome and retinitis pigmentosa, and it's for anyone interested in understanding these conditions better and finding new ways to treat them.

  NIH research University of California at Davis · Davis, United States · NIH-10879166

• Gene therapy for brain diseases using cerebrospinal fluid delivery

  This study is exploring a new way to treat alpha-mannosidosis, a genetic brain condition, by using gene therapy delivered directly into the fluid around the brain to help fix the underlying issues and improve brain function.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10599930

Related topics

Quick answers

How many Brain Disease clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (8 trials), Italy (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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