New technology for capturing tissue samples in Barrett's Esophagus patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates a novel approach called in-vivo laser capture microdissection (IVLCM) using a tethered capsule endomicroscope to improve the assessment of Barrett's Esophagus. Patients swallow a capsule that captures images of the esophagus and identifies abnormal tissue in real-time. A laser is then used to capture targeted tissue samples for genomic analysis, allowing for more precise risk assessment of esophageal adenocarcinoma. The study aims to enhance the accuracy of Barrett's Esophagus screening and prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants must have a current or prior diagnosis of Barrett's Esophagus
* Participants must be over the age of 18.
* Participants must be able to give informed consent.

Exclusion Criteria:

* Pregnant women.
* Participants who are on anti-platelet medications or anti-coagulation medications, and NSAIDS at the time of procedure.
* Participants with a history of hemostasis disorders.
* Participants with esophageal strictures, resulting in a luminal diameter smaller than the diameter of the capsule.
* Participants with a know history of esophageal varices
* Participants above 80 years of age

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Gary Tearney, MD., PhD — Massachusetts General Hospital
• Study coordinator: Anita Chung, RN
• Email: Tearneylabtrials@partners.org
• Phone: 617-724-4515

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Stopping routine endoscopic surveillance for low-risk Barrett's esophagus (BLISS Project)

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• Non-endoscopic test to find Barrett's esophagus in veterans without chronic reflux.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.