Drug or treatment

Avutometinib clinical trials

• 10Clinical trials
• 16Countries

Newest trials

All recruiting trials (10)

• Avutometinib, Defactinib, and Everolimus for RAS-pathway Mutant Endometrial Cancer

  This study tests a three-drug combination to see if it’s safe and how it works in patients with recurrent endometrial cancer that has RAS pathway mutations.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT07318324

• Combination therapy for malignant brain tumors using avutometinib and defactinib

  This study is testing a new combination of two drugs, avutometinib and defactinib, to see if they can help people with advanced malignant brain tumors like glioblastoma feel better and improve their treatment options.

  Recruiting at 3 sites Phase 1/2 Institute of Cancer Research, United Kingdom · Cambridge and 2 other locations · NCT06630260

• Combination treatment for advanced lung cancer with specific mutations

  This study is testing a new combination of medications for people with advanced lung cancer that has specific mutations and hasn't improved with other treatments, to see if it helps them live longer without the cancer getting worse.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 2 other locations · NCT06495125

• Combination treatment for diffuse gastric cancer using avutometinib and defactinib

  This study is testing a new combination of two oral drugs, avutometinib and defactinib, to see if they can help people with advanced stomach cancer live longer and shrink their tumors after chemotherapy.

  Recruiting Phase 2 Columbia University · New York, New York · NCT06487221

• Combination treatment for low-grade serous ovarian cancer

  This study is testing a new combination of three drugs to see if it can help women with low-grade serous ovarian cancer feel better and improve their condition.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Atlanta, Georgia and 7 other locations · NCT06394804

• Combination treatment for advanced colorectal cancer

  This study is testing a new combination of three drugs to see if it can help people with advanced colorectal cancer that hasn't responded to other treatments.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06369259

• Treatment for brain metastases from melanoma using defactinib and avutometinib

  This study is testing if a combination of two drugs, defactinib and avutometinib, can help people with brain tumors from melanoma feel better after their previous treatments didn't work.

  Recruiting at 2 sites Phase 1/2 University of Utah · Iowa City, Iowa and 1 other locations · NCT06194929

• Combination treatment for recurrent low-grade serous ovarian cancer

  This study is testing a new combination of two drugs for people with recurrent low-grade serous ovarian cancer to see if it helps them live longer without their cancer getting worse compared to standard treatments.

  Recruiting at 103 sites Phase 3 Verastem, Inc. · Phoenix, Arizona and 104 other locations · NCT06072781

• Combination treatment for thyroid cancer using avutometinib and defactinib

  This study is testing a new combination of two drugs, avutometinib and defactinib, to see if they can help patients with hard-to-treat thyroid cancer feel better and have more options for their treatment.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06007924

• Testing a new drug combination for certain types of gynecological cancers

  This study is testing a new combination of two drugs to see if they can help people with certain types of gynecological cancers feel better and improve their treatment outcomes.

  Recruiting at 4 sites Phase 2 University of Oklahoma · Orlando, Florida and 3 other locations · NCT05512208

Quick answers

How many clinical trials of Avutometinib are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (9 trials), United Kingdom (2 trials), Australia (1 trial), Belgium (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 2, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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