Investigating blood proteins related to heart failure
Official title: Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
Run by UConn Health · NCT00762008 · Data updated 2026-11-12
This study is trying to see if two specific proteins in the blood can help identify when people with heart failure are having a worsening episode.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | UConn Health Academic / other |
| Locations | 1 site (Farmington, Connecticut) |
| Status | Recruiting |
| Started | December 2005 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | August 17, 2026 |
| Trial ID | NCT00762008 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals over 18 years with stable or decompensated heart failure symptoms, as well as healthy individuals without a history of heart issues for comparison.
✕Probably not a fit
Patients who have undergone recent cardiac or non-cardiac surgery or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to identify whether two specific proteins in the blood are elevated during episodes of acute heart failure. These proteins are produced when the heart's function deteriorates, and their levels may indicate the transition from compensated hypertrophy to acute heart failure. The study will analyze blood samples from individuals with heart failure and healthy controls to establish a correlation between protein levels and heart failure symptoms. By understanding these biomarkers, the research seeks to improve early detection and prevention strategies for heart failure.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of heart failure, potentially reducing morbidity and mortality.
How similar studies have gone: While the study explores a novel approach to identifying biomarkers for heart failure, previous studies have shown the importance of biomarkers like BNP in heart failure diagnosis, indicating potential for success in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals aged \>18yrs * stable or decompensated heart failure, irrespective of LVEF * decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites * Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures) * Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls. Exclusion Criteria: * Subjects who are unable to give informed consent * Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment * Pregnant subjects are not excluded
Where it's running
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University of Connecticut Health Center
Farmington, Connecticut, United States Recruiting
Study contacts
- Principal investigator: Bruce T. Liang, M.D. — UConn Health
- Study coordinator: Kristen Siedlarz, MA
- Email: siedlarz@uchc.edu
- Phone: 860-679-7549
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.