PANDA-ASOCT: Detecting Uveitis in Children with Automated Eye Image Analysis
Official title: An Observational Longitudinal Cohort Study on the Clinical Application of Anterior Segment Ocular Coherence Tomography (AS-OCT) as an Imaging Tool in Detecting, Grading and Monitoring Non-infectious Anterior Uveitis, in Age 2 to 16 Years Old, in a Single Regional Multi-disciplinary Paediatric Uveitis Service, Comparing With the Standard Slit Lamp Examination, and Development of Deep Learning in Automated Analysis
Run by Sheffield Children's NHS Foundation Trust · NCT07813598 · Data updated 2026-11-12
This study tests a high-speed, non-invasive eye imaging system with automated analysis to help detect uveitis in children and young people who attend a clinic for uveitis or juvenile idiopathic arthritis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years to 16 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Sheffield Children's NHS Foundation Trust Academic / other |
| Locations | 1 site (Sheffield, South Yorkshire) |
| Status | Recruiting |
| Started | September 9, 2026 |
| Main results expected | February 2027 |
| Study ends | February 2027 |
| Registry record updated | September 15, 2026 |
| Trial ID | NCT07813598 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 2 to 16 years who are attending a uveitis or JIA-uveitis clinic at Sheffield Children's Hospital and have consent/assent.
✕Probably not a fit
Children who do not have uveitis or inflammatory eye activity, or who cannot undergo ASOCT imaging, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Uveitis in children can be a silent condition that risks permanent vision loss if not detected. The study uses a high-resolution, non-irradiating ASOCT imaging system that scans the front of the eye in about 1.2 seconds and analyzes inflammatory cell signals with automated algorithms. It will compare imaging results with standard eye examinations in about 300 pediatric patients to see if the new method can predict disease activity and monitor treatment response. Slit lamp examination and ASOCT are the core observational methods, conducted at Sheffield Children's Hospital. The goal is to determine whether automated image analysis can improve detection and monitoring of pediatric uveitis.
Why it matters
Potential benefit: If successful, the approach could enable earlier, non-invasive detection and better monitoring of uveitis in children, potentially reducing the risk of vision loss.
How similar studies have gone: Previous work with imaging-based automated analysis in ocular inflammation supports the potential value, but this specific high-speed, automated ASOCT approach in children is novel within this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 2 and 16 years * Attending uveitis and JIA-uveitis clinic at Sheffield Children's Hospital * Parents/carers give informed written consent and CYP give age-appropriate assent Exclusion Criteria: * Unable to obtain parental/carer written consent * CYP does not want to be recruited
Where it's running
-
Sheffield Children's Hospital
Sheffield, South Yorkshire, United Kingdom Recruiting
Study contacts
- Study coordinator: Research and Development Manager
- Email: research.sheffchild@nhs.net
- Phone: 01142260748
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.