Metagenomic testing for infections in people with eye inflammation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project applies metagenomic sequencing to aqueous humor samples and pairs results with ocular imaging to look for infectious causes when standard testing is inconclusive. Participants are adults (≥18) with active ocular inflammation at risk of vision loss and a clinical suspicion of an infectious or para-infectious trigger. Samples will be processed using methods previously optimized for central nervous system infections to detect bacteria, viruses, fungi, and parasites. Patients requiring an urgent result within five days or who cannot safely undergo ocular fluid sampling are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 18 years of age or older with the capacity to consent
2. Standard of care has not determined a clinical diagnosis
3. Active ocular inflammation with risk of visual loss
4. Clinically suspected infectious or para-infectious cause of ocular inflammation

Exclusion Criteria:

1. Contraindication to ocular fluid sampling
2. Where an urgent result within 5 days is clinically required

Where it's running

• Moorfields Eye Hospital NHS Foundation Trust
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Research Administration at Moorfields Eye Hospital R&D
• Email: moorfields.crfenquiries@nhs.net
• Phone: +44 20 7253 2411

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.