Two bovine bone grafts in sinus lift with or without jaw marrow blood

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 25–65 with insufficient bone height in the upper jaw will receive lateral window sinus augmentation using one of four graft combinations: Bio-Oss alone, InterOss alone, Bio-Oss plus jawbone marrow blood, or InterOss plus jawbone marrow blood. Each sinus is randomly assigned to a treatment, and patients with two treated sides may receive different treatments on each side. The trial looks at how much new vital bone forms and how much height increases, comparing the two graft materials and the effect of adding mandibular marrow blood. Autologous marrow blood is collected minimally invasively from the jaw to mix with the graft in the relevant arms. The goal is to determine whether mixing with marrow blood improves outcomes and whether the two grafts perform similarly.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged 25 to 65 years.
* Partially edentulous posterior maxilla requiring lateral window maxillary sinus floor augmentation prior to dental implant placement.
* Residual alveolar bone height of 6 mm or less in the sinus area, measured on preoperative cone beam CT.
* Non-smokers.
* Good oral hygiene.
* Good general health (ASA physical status I or II).
* Adequate anatomical availability of mandibular medullary bone, assessed on cone beam CT.
* Willing to participate and able to provide written informed consent.

Exclusion Criteria:

* Uncontrolled or untreated systemic disease.
* Untreated psychiatric disorders.
* Drug abuse.
* Pre-existing acute or chronic sinus pathology.
* Any blood disorder.

Where it's running

• Universidad del Desarrollo (UDD)
  Santiago, Santiago Metropolitan, Chile Recruiting

Study contacts

• Principal investigator: Claudio M Miranda, DDS — Universidad del Desarrollo
• Study coordinator: Claudio M Claudio Miranda, DDS, Director
• Email: clmirandacar@gmail.com
• Phone: +56 (2) 2327 9110

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.