Reduced wait time for implant placement after socket preservation with Vega Plus implants

Effect of Reducing the Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implant System (Klockner): A Randomized Controlled Clinical Trial

This will test whether placing a single-tooth Vega Plus implant four months after extraction and ridge preservation works as well or better than waiting six months for adults who need a single-tooth implant.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Universidad Catolica Santiago de Guayaquil (other)
• Locations: 1 site (Guayaquil, Guayas)
• Trial ID: NCT07484685 on ClinicalTrials.gov

What this trial studies

This randomized controlled trial will enroll adults who require single-tooth extraction and implant therapy in incisors, canines, or premolars and randomly assign them to implant placement at either four months (reduced interval) or six months (standard interval) after ridge preservation using the Vega Plus implant system. Clinical and radiographic assessments, including baseline and scheduled follow-up visits, will use CBCT to measure ridge width and height, resonance frequency analysis for implant stability (ISQ), standardized periapical radiographs for marginal bone levels, and VAS for postoperative pain. The primary outcome is mean change in horizontal alveolar ridge width on CBCT, with secondary outcomes comparing vertical bone height, implant stability, marginal bone changes, and patient-reported symptoms. Group comparisons will determine whether the reduced-interval protocol maintains or improves clinical and radiographic outcomes while shortening overall treatment time.

Who should consider this trial

Good fit: Adults (≥18 years) needing single-tooth extraction and implant placement in an incisor, canine, or premolar with three intact socket walls (≥50% buccal wall defect allowed), sufficient CBCT-assessed bone for a 3.6×10 mm implant, good general health, and low plaque/bleeding scores are ideal candidates.

Not a fit: Patients with systemic conditions or medications that impair healing (for example uncontrolled diabetes, recent cancer treatment, HIV, high‑dose steroids, or bisphosphonate use), inadequate bone for the specified implant size, or those requiring molar implants are unlikely to receive benefit from this protocol.

Why it matters

Potential benefit: If successful, this approach could shorten overall treatment time while preserving bone and implant stability, making implant therapy faster and more convenient for patients.

How similar studies have performed: Emerging clinical reports suggest reduced healing intervals can be effective in some implant cases, but randomized data specifically using the Vega Plus system are limited.

Eligibility criteria

Inclusion Criteria:

* Age: ≥ 18 years.
* Good general health.
* Need of extraction of incisors, canines or premolars due to carious lesion, endodontic complication, root fracture or prosthetic reason.
* Presence of three intact socket walls after tooth extraction with a defect of 50% or more of the buccal wall.
* Need of single-tooth implant treatment, with presence of adjacent teeth and opposing occluding teeth (for measurement stent indexing).
* Enough available bone assessed on CBCT to place implants with 3.6 mm diameter and 10 mm in length.
* Periodontal health in intact or reduced periodontium.
* Full-mouth plaque and bleeding scores \< 20%.
* Able and willing to follow study procedures and instructions.

Exclusion Criteria:

* \< 18 years.
* Compromised health. Existence of any systemic condition such as uncontrolled diabetes mellitus, cancer, HIV, disorders that compromise wound healing, chronic high dose steroid therapy, intravenous and oral bisphosphonate therapy, bone metabolic diseases, history of irradiation of the head and neck area, or any other immunosuppressive therapy that would contraindicate oral surgical treatment.
* Absence of any adjacent teeth or the opposing occluding teeth.
* The hopeless tooth is a molar.

Where this trial is running

Guayaquil, Guayas

• Universidad Catolica Santiago de Guayaquil- Carrera de Odontologia de La Ucsg — Guayaquil, Guayas, Ecuador (RECRUITING)

Study contacts

• Study coordinator: GABRIELA GUADALUPE ZAMBRANO MANZABA, DDS

Conditions: Alveolar Bone Loss, Tooth Extraction, Dental implant, Tooth extraction, Alveolar ridge preservation, Guided Bone Regeneration, Bone regeneration, Dental Implant Placement