Stem cell exosomes versus platelet-rich fibrin for healing after a tooth extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind trial enrolls 40 adults who need a single non-infected extraction in the aesthetic or premolar zone and assigns them to receive either MSC-derived exosomes or autologous PRF placed in the socket after atraumatic extraction. Outcomes are measured with baseline and 3-month cone beam CT (CBCT) scans to compare changes in alveolar bone density and ridge dimensions. Secondary measures include soft tissue healing by the Landry Index and patient-reported pain and swelling. The trial tests whether a cell-free exosome approach provides more standardized or improved ridge preservation compared with the current PRF technique.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 20 and 45 years.
* Patients requiring a single tooth extraction of a non-infected tooth in the aesthetic zone (incisors, canines) or premolar area.
* Presence of adjacent teeth to the extraction site.
* Adequate oral hygiene (Plaque Index \< 20%).
* Patients willing and able to comply with the follow-up schedule and 3-month CBCT scan.
* Signed informed consent provided by the participant.

Exclusion Criteria:

* Patients with systemic diseases that contraindicate oral surgery or interfere with bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism).
* History of head and neck radiation therapy or bisphosphonate medication use.
* Active infection or acute abscess at the extraction site.
* Heavy smokers (more than 10 cigarettes per day).
* Pregnant or lactating women.
* Patients with poor oral hygiene or active periodontal disease in the rest of the mouth.
* Use of any medications known to affect bone metabolism (e.g., long-term corticosteroids).

Where it's running

• Department of Oral & Maxillofacial Surgery, Al Salam University
  Tanta, Gharbia Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Omaima M Sakr, BDS, MSc, PhD — Al Salam University, Faculty of Oral & Dental Medicine, Egypt
• Study coordinator: Omaima M Sakr, BDS, MSc, PhD
• Email: drsakr2009@hotmail.com
• Phone: +201001051538

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.