Melatonin Gel in Immediate Molar Implants in the Back of the jaw
Official title: Clinical and Radiographic Assessment of the Osteogenic Effect of Melatonin in Immediate Implant Placement: A Pilot Randomized Clinical Trial.
Run by Future University in Egypt · NCT07869030 · Data updated 2026-11-12
In this small study, researchers test whether applying a 1% melatonin gel during immediate molar implant placement in the back of the lower jaw helps with healing and bone formation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 50 Years |
| Sex | All |
| Enrollment | 16 (estimated) |
| Sponsor | Future University in Egypt Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | November 6, 2025 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT07869030 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults 20–50 needing immediate posterior mandibular molar implants, non-smokers or light smokers, and able to attend follow-ups.
✕Probably not a fit
Patients with systemic bone healing disorders, heavy smoking, or major wound-healing risks may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot randomized trial compares immediate posterior mandible implants with or without a 1% melatonin gel in the socket. Participants are healthy adults aged 20–50 and are randomized to receive either the melatonin treatment or standard care, using customized healing abutments in both groups. The study looks at bone density and buccal bone thickness by CBCT, implant stability over several months, and soft-tissue healing to estimate variability and feasibility for future trials. It is conducted at Future University in Egypt with a total of 16 participants (8 per group).
Why it matters
Potential benefit: If successful, the melatonin gel could improve bone healing and implant stability after immediate mandibular implants.
How similar studies have gone: Previous work in related bone healing uses of melatonin show potential, but this exact protocol in immediate implant sockets is exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 20-50 years. * Indicated for extraction and immediate implant placement in the posterior mandibular molar region. * Good oral hygiene and compliance with postoperative instructions. * Non-smokers or light smokers (≤10 cigarettes/day). * Patients who provide written informed consent and agree to attend follow-up visits. Exclusion Criteria: * Patients with systemic diseases affecting bone metabolism or wound healing (e.g., uncontrolled diabetes, osteoporosis). * Heavy smokers (\>10 cigarettes/day). * History of head and neck radiotherapy or chemotherapy. * Pregnant or lactating women. * Sites with acute infection, cystic lesions, or pathology. * Bruxism or parafunctional habits. * Use of medications affecting bone turnover (e.g., bisphosphonates, corticosteroids). * Poor compliance or unwillingness to return for follow-up visits.
Where it's running
-
Department of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Medicine - Future University in Egypt
Cairo, Egypt Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Two bovine bone grafts in sinus lift with or without jaw marrow blood
This study tests whether adding a small amount of jawbone marrow blood to two bovine bone grafts helps create more new bone and height in sinus lift surgery for adults needing implants.
-
Dental Abutments With Different Surfaces in Two-Unit Implant Bridges
This study tests whether two different abutment surface types affect outcomes for people needing two-implant-supported, two-unit bridges in the back of the mouth.
-
Lactoferrin Gel for Healing and Implant Stability in Immediate Mandibular Molars
A 4% bovine lactoferrin nanohydrogel is being tested to see if it helps soft tissue and bone heal better and improve implant stability after immediate mandibular molar implants.
-
Bone marrow cells plus Bio-Oss graft for repairing severe jawbone defects
This study tests whether using a patient’s own bone marrow–derived mononuclear cells mixed with Bio-Oss graft can repair severe maxillofacial bone defects in adults aged 18-60.
-
Porous zirconia shell to widen the jawbone before implants
A small group of adults with a narrow lower back jaw will try a custom porous zirconia shell placed over bone grafts to see if it helps form good-quality new bone before placing dental implants.
-
Immediate molar implants with customized healing abutments in different socket classes
This study tests placing an implant right after extracting a back tooth and using a custom healing cap to shape the gum from day one, in people needing posterior implants.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.