Registry for Spontaneous Coronary Artery Dissection
Official title: The "Virtual" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry
Run by Mayo Clinic · NCT01429727 · Data updated 2026-11-12
This study is trying to gather information about people with Spontaneous Coronary Artery Dissection to better understand the condition and improve treatment and prevention.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | July 2011 |
| Main results expected | December 2030 |
| Study ends | December 2030 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT01429727 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with SCAD, particularly women who are pregnant or postpartum, underrepresented racial or ethnic groups, men, and younger patients.
✕Probably not a fit
Patients with a history of SCAD who do not meet the updated inclusion criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to describe the clinical and physiological characteristics of Spontaneous Coronary Artery Dissections (SCAD) to enhance awareness, understanding, treatment, and prevention of this serious cardiovascular condition. The study involves both retrospective and prospective reviews of the medical histories and current health of individuals diagnosed with SCAD. By building a comprehensive database of SCAD patients, the research seeks to identify patterns in incidence, causes, and associations that could inform future studies and improve patient outcomes.
Why it matters
Potential benefit: If successful, this registry could lead to better understanding and management of SCAD, ultimately improving patient care and outcomes.
How similar studies have gone: While SCAD is a relatively novel area of research, the establishment of registries for rare conditions has shown promise in other studies, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who have been cared for at Mayo Clinic with a diagnosis of SCAD * SCAD in women who are pregnant or within 12 months postpartum at the time of SCAD * SCAD in individuals who self-identify as a member of a racial or ethnic group that is currently underrepresented in the registry. This would include anyone who identifies as: Black/African American, Asian, American Indian or Alaska Native, Native Hawaiian or Other Pacific Islander, and any race with Hispanic ethnicity * SCAD in a man * SCAD in persons younger than 30 years of age * SCAD within the past 2 weeks (acute) * SCAD patient enrolling into any other Mayo Clinic SCAD Research Study * SCAD in individuals who have a relative that has had a SCAD event Persons with history of SCAD who are interested in participating in the study but do not meet the updated inclusion criteria will not be enrolled at this time. However, they will be given the option to share their contact information in order to be invited to future Mayo Clinic SCAD studies.
Where it's running
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Mayo Clinic
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Marysia S Tweet, M.D., M.S. — Mayo Clinic
- Study coordinator: Susan Milbrandt
- Email: mayoscad@mayo.edu
- Phone: 507-266-3180
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Observational study on spontaneous coronary artery dissection
This study is trying to learn more about spontaneous coronary artery dissection (SCAD) by following 3,000 patients over 10 years to better understand who it affects and how to treat it.
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Genetic causes of spontaneous coronary artery dissection
This project will test whether inherited or new gene changes cause spontaneous coronary artery dissection in adults with SCAD and their biological relatives.
-
Survey of physical activity and quality of life for people with fibromuscular dysplasia
This national survey asks adults with fibromuscular dysplasia to see if activity restrictions affect their quality of life and emotional well-being.
-
Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia
This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.
-
Norwegian SCAD follow-up and outcomes program
This program will follow adults hospitalized with SCAD in Norway for one year to see if scheduled imaging, tests, and questionnaires identify complications and risk factors.
-
Stress contrast echocardiography in adults with prior SCAD
This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.