Genetic causes of spontaneous coronary artery dissection
Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
This project will test whether inherited or new gene changes cause spontaneous coronary artery dissection in adults with SCAD and their biological relatives.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT01427179 on ClinicalTrials.gov |
What this trial studies
The study creates a genomic DNA and plasma biobank from adults with angiographically confirmed SCAD and from their biological parents and affected relatives. Researchers will search for inherited and de novo mutations and look for common genetic variants that increase SCAD risk using genomic analyses. Participants are identified both retrospectively and prospectively, with diagnosis confirmed by coronary angiogram review before consent and sample collection. Long-term goals include defining molecular mechanisms and developing biomarkers to improve prediction and prevention of SCAD.
Who should consider this trial
Good fit: Adults with one or more confirmed episodes of SCAD who can give informed consent, and their biological parents or relatives with fibromuscular dysplasia, arterial aneurysm, or arterial dissection willing to provide samples.
Not a fit: People without angiographic confirmation of SCAD or those unable to provide informed consent or a blood/saliva sample are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this work could enable genetic tests and biomarkers to identify people at higher risk for SCAD and support family screening and prevention strategies.
How similar studies have performed: Some prior genetic and genome-wide studies have found risk loci suggesting a genetic contribution to SCAD, but comprehensive inherited and de novo mutation analysis remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women able to give informed consent and complete a 2 page questionnaire * Diagnosis of one or more episodes of spontaneous coronary artery dissection (SCAD) * Biological parent of individual with SCAD * Relative with fibromuscular dysplasia, arterial aneurysm, or arterial dissection Exclusion Criteria: * Lack of confirmation of SCAD diagnosis
Where this trial is running
Rochester, Minnesota
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Sharonne N. Hayes, M.D. — Mayo Clinic
- Study coordinator: Jake Nemgar
- Email: MayoSCAD@Mayo.edu
- Phone: 5072663180
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.