Genetic causes of spontaneous coronary artery dissection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study creates a genomic DNA and plasma biobank from adults with angiographically confirmed SCAD and from their biological parents and affected relatives. Researchers will search for inherited and de novo mutations and look for common genetic variants that increase SCAD risk using genomic analyses. Participants are identified both retrospectively and prospectively, with diagnosis confirmed by coronary angiogram review before consent and sample collection. Long-term goals include defining molecular mechanisms and developing biomarkers to improve prediction and prevention of SCAD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women able to give informed consent and complete a 2 page questionnaire
* Diagnosis of one or more episodes of spontaneous coronary artery dissection (SCAD)
* Biological parent of individual with SCAD
* Relative with fibromuscular dysplasia, arterial aneurysm, or arterial dissection

Exclusion Criteria:

* Lack of confirmation of SCAD diagnosis

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Sharonne N. Hayes, M.D. — Mayo Clinic
• Study coordinator: Jake Nemgar
• Email: MayoSCAD@Mayo.edu
• Phone: 5072663180

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Observational study on spontaneous coronary artery dissection

  This study is trying to learn more about spontaneous coronary artery dissection (SCAD) by following 3,000 patients over 10 years to better understand who it affects and how to treat it.

  Recruiting Cardiology Research UBC · Vancouver, British Columbia · NCT04906356

• Registry for Spontaneous Coronary Artery Dissection

  This study is trying to gather information about people with Spontaneous Coronary Artery Dissection to better understand the condition and improve treatment and prevention.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT01429727

• Survey of physical activity and quality of life for people with fibromuscular dysplasia

  This national survey asks adults with fibromuscular dysplasia to see if activity restrictions affect their quality of life and emotional well-being.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07529691

• Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia

  This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07526766

• Norwegian SCAD follow-up and outcomes program

  This program will follow adults hospitalized with SCAD in Norway for one year to see if scheduled imaging, tests, and questionnaires identify complications and risk factors.

  Recruiting at 3 sites Oslo University Hospital · Bergen and 2 other locations · NCT07317323

• Stress contrast echocardiography in adults with prior SCAD

  This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07178509

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.