Observational study on spontaneous coronary artery dissection
Canadian Spontaneous Coronary Artery Dissection (SCAD) Study and Genetic Sub-study (Prospective, Observational Registry With 10 Year Follow-up)
This study is trying to learn more about spontaneous coronary artery dissection (SCAD) by following 3,000 patients over 10 years to better understand who it affects and how to treat it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cardiology Research UBC Academic / other |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT04906356 on ClinicalTrials.gov |
What this trial studies
The Canadian SCAD Study is a multicenter, prospective observational registry aimed at understanding the natural history of spontaneous coronary artery dissection (SCAD) and its associated conditions. This study will enroll 3,000 patients over a 10-year follow-up period, focusing on the demographics, predisposing factors, and treatment strategies for SCAD. By collecting data from major cardiac centers across Canada and internationally, the study seeks to address the gaps in knowledge regarding SCAD, which often affects young women and is frequently misdiagnosed. The findings will help inform future randomized controlled trials and improve management strategies for SCAD patients.
Who should consider this trial
Good fit: Ideal candidates include patients admitted with acute coronary syndrome who have documented SCAD on a coronary angiogram.
Not a fit: Patients whose SCAD is attributed to atherosclerotic coronary artery disease will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better diagnosis and management strategies for patients suffering from SCAD.
How similar studies have performed: While SCAD has been under-researched, this study builds on previous efforts and aims to fill significant knowledge gaps, making it a novel approach in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients admitted with ACS (STEMI, NSTEMI or unstable angina) 2. Documented SCAD on a coronary angiogram (including diagnosis with OCT or IVUS) Exclusion Criteria: 1\. Patients where SCAD is attributed to atherosclerotic coronary artery disease, with atherosclerotic coronary artery disease stenosis ≥50%
Where this trial is running
Vancouver, British Columbia
- Vancouver General Hospital — Vancouver, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Jacqueline Saw, MD — Cardiology Research UBC / Vancouver General Hospital
- Study coordinator: Andrew Starovoytov, MD
- Email: a.starovoytov@ubc.ca
- Phone: 6048755079
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.