Preoperative NPAR and Post-Induction Hemodynamic Vulnerability in Major Oncologic Surgery
Official title: Preoperative Neutrophil Percentage-to-Albumin Ratio as a Predictor of Post-Induction Hemodynamic Vulnerability in Major Oncologic Surgery
Run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · NCT07804706 · Data updated 2026-11-12
This study checks if the preoperative neutrophil percentage-to-albumin ratio (NPAR) can flag who might become hemodynamically unstable after anesthesia induction in adults having major cancer surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital Academic / other |
| Locations | 1 site (Ankara, Yeni̇mahalle) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | September 9, 2026 |
| Trial ID | NCT07804706 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older scheduled for elective major oncologic surgery under general anesthesia with available preoperative CBC and albumin measurements and standard hemodynamic monitoring.
✕Probably not a fit
Patients lacking preoperative lab data or who do not experience post-induction hemodynamic vulnerability may not derive direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will analyze routinely collected preoperative labs to calculate NPAR and relate it to hemodynamic vulnerability after induction of general anesthesia, within a 20-minute window before incision. No changes to anesthesia care or additional tests are introduced. Data will include demographics, ASA status, labs, induction details, fluids, and vasopressor use to identify associations between NPAR and post-induction instability. Approximately 220 adult patients undergoing elective major oncologic surgery will be enrolled using consecutive sampling. The study will classify participants by presence or absence of post-induction hemodynamic vulnerability and will not modify standard clinical management.
Why it matters
Potential benefit: If successful, NPAR could help clinicians anticipate which patients are at risk for post-induction hypotension and tailor perioperative care accordingly.
How similar studies have gone: Prior work has explored inflammatory and nutritional markers as predictors of perioperative risk, but this exact NPAR-post-induction vulnerability relationship is under investigation and not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Scheduled for elective major oncologic surgery * Undergoing surgery under general anesthesia * Availability of preoperative complete blood count and serum albumin -measurements * Standard hemodynamic monitoring * Provision of written informed consent for participation in the study Exclusion Criteria: * Age younger than 18 years * Emergency surgery * Preoperative hemodynamic instability * Preoperative vasopressor or inotropic support * Sepsis or active infection * Hematologic malignancy * Advanced cardiac, renal, or hepatic failure * Pregnancy * Missing preoperative laboratory data -Inability to complete the 20-minute post-induction evaluation period-
Where it's running
-
Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital
Ankara, Yeni̇mahalle, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Mustafa Kemal SAHIN, M.D
- Email: Mksahin@msn.com
- Phone: +5075800976
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.