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Clinical trial Recruiting at 1 site Interventional Ages 18 to 45 Women only

Mindfulness-based breathing before spinal anesthesia for elective cesarean delivery

Official title: "The Effect of a 5-Minute Mindfulness-Based Breathing Exercise Administered Prior to Spinal Anesthesia on Hemodynamic Response in Patients Undergoing Elective Cesarean Section: A Prospective Randomized Controlled Trial"

Run by Ataturk University · NCT07494955 · Data updated 2026-11-12

This trial will test whether a 5-minute mindfulness slow-breathing exercise just before spinal anesthesia can reduce blood pressure drops and anxiety in pregnant women having elective cesarean delivery.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexWomen only
Enrollment150 (estimated)
SponsorAtaturk University
Academic / other
Locations1 site (Erzurum)
StatusRecruiting
StartedMarch 1, 2026
Main results expectedMarch 1, 2028
Study endsMarch 1, 2028
Registry record updatedApril 1, 2026
Trial IDNCT07494955 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are pregnant women aged 18–45 years with a singleton pregnancy at ≥37 weeks, ASA physical status II, BMI ≤35 kg/m2, able to follow verbal instructions, and scheduled for elective cesarean under spinal anesthesia who can provide informed consent.

Probably not a fit

Patients with emergency cesarean sections, hypertensive disorders of pregnancy, multiple gestation, significant cardiac or pulmonary disease, chronic autonomic dysfunction, or contraindications to spinal anesthesia are unlikely to be eligible or to benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, parallel-group trial comparing a standardized 5-minute mindfulness-based slow-breathing exercise to standard preoperative care in women scheduled for elective cesarean under spinal anesthesia. Participants are randomized 1:1 and the breathing intervention targets approximately six breaths per minute with diaphragmatic technique delivered immediately before spinal placement. The study will monitor hemodynamic responses intraoperatively, including incidence and severity of spinal anesthesia–induced hypotension, vasopressor use, and perioperative anxiety measures. Data will be used to determine whether a brief autonomic-modulating intervention can alter physiologic responses to neuraxial blockade in this population.

Why it matters

Potential benefit: If successful, this low-cost, nonpharmacologic intervention could reduce the frequency or severity of spinal anesthesia–related hypotension and lower vasopressor requirements during elective cesarean deliveries.

How similar studies have gone: Small prior studies of paced breathing and brief mindfulness have shown reductions in anxiety and favorable autonomic changes, but evidence specifically demonstrating prevention of spinal anesthesia–induced hypotension during cesarean is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

Pregnant women aged 18-45 years Singleton pregnancy Gestational age 37 weeks or greater American Society of Anesthesiologists (ASA) physical status classification II Scheduled for elective cesarean section under spinal anesthesia Body mass index (BMI) 35 kg/m2 or less Ability to comprehend verbal instructions and perform the breathing exercise Provision of written informed consent

Exclusion Criteria:

Emergency cesarean section Hypertensive disorders of pregnancy (gestational hypertension, preeclampsia, eclampsia, HELLP syndrome) Placenta previa, placental abruption, or active antepartum hemorrhage Multiple pregnancy Contraindications to spinal anesthesia Failed spinal anesthesia requiring conversion to general anesthesia Chronic hypertension or chronic hypotension Known cardiac disease (arrhythmia, valvular disease, cardiomyopathy) Diabetes mellitus with autonomic neuropathy Thyroid dysfunction Chronic pulmonary disease potentially affecting respiratory pattern Body mass index greater than 35 kg/m2 Regular use of beta-blockers, calcium channel blockers, alpha-agonists, or alpha-antagonists Regular use of anxiolytics, antidepressants, sedatives, or chronic opioids Diagnosed anxiety disorder, panic disorder, major depressive disorder, or other psychiatric illness Regular use of psychiatric medications Cognitive impairment or communication difficulties Attention or compliance problems precluding adequate performance of the breathing exercise Prior regular practice of meditation, yoga, or mindfulness-based training

Where it's running

  • Atatürk University Research Hospital
    Erzurum, Turkey (Türkiye)     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Hypotension 38Cesarean Section 42Hemodynamic Instability 21Ataturk University 30
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.