Phenotype-based pain management for chronic post-treatment pain after head and neck cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot Phase 2 interventional trial explores a phenotype-driven approach to managing chronic post-treatment pain in adults who have finished curative therapy for head and neck cancer. Participants undergo three visits over one month, complete pain and mood questionnaires, and receive a pain-phenotype assessment to guide a tailored treatment plan that may include medications, trigger point injections, or nerve blocks. The study aims to determine whether the approach can reduce average pain by at least 75% after four weeks and to evaluate safety, with a limit on treatment-related dropouts. Eligibility includes adults with a history of curative treatment and persistent chronic pain, and exclusions cover active disease, infection, wound issues, or cognitive impairment affecting questionnaire completion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years) with history of curative treatment for head and neck cancer
* Chronic post-treatment pain disorder
* Absence of clinical and radiological evidence of recurrent disease
* Ability to provide informed consent

Exclusion Criteria:

* Active disease recurrence or metastasis
* Persistent mucositis, oral infection, or hardware failure at the treatment site
* Surgical wound dehiscence
* Cognitive impairment that limits the ability to complete study questionnaires

Where it's running

• Shaukat Khanum Memorial Cancer Hospital & Research Centre
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Khawaja S Nasir
• Email: shehryarnasir@skm.org.pk
• Phone: 924235905000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.