Measuring lung mechanics in patients on mechanical ventilation
"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"
This study is testing how mechanical ventilation affects lung function in patients with breathing problems to help improve their care and reduce lung injury.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Göteborg University Academic / other |
| Locations | 1 site (Gothenburg, Västra Götaland County) |
| Trial ID | NCT04484727 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate how lung mechanics are affected during the early phase of mechanical ventilation in patients with respiratory distress. It utilizes a non-invasive PEEP-step method to assess the elastic properties of the lungs, allowing for improved monitoring and individualized ventilator care. The study will collect data from both healthy lungs and those with acute lung failure, focusing on the first hours of ventilator treatment. This approach seeks to enhance the understanding of lung mechanics and potentially reduce ventilator-induced lung injury.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old who are undergoing planned or acute ventilator treatment in an intensive care unit or operating room.
Not a fit: Patients under 18 years old or those with severe respiratory or cardiac conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better monitoring and management of ventilator therapy, reducing the risk of lung injury and improving patient outcomes.
How similar studies have performed: While there is limited data on lung mechanics during the initial hours of ventilation, the non-invasive PEEP-step method represents a novel approach that has not been extensively tested in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients above18 years * ASA 1-3 * Planned/acute ventilator treatment in ICU or OR Exclusion Criteria: * Patients under 18 years * ASA 4 and above * severe COPD/emphysema/heart failure * PEEP\>16 and/or FiO2 \>80% * elevated intracranial pressure * defect coagulation * non-treated known or suspected pneumothorax
Where this trial is running
Gothenburg, Västra Götaland County
- Sophie Lindgren — Gothenburg, Västra Götaland County, Sweden (Recruiting)
Study contacts
- Study coordinator: Sophie Lindgren, Assoc prof
- Email: sophie.lindgren@vgregion.se
- Phone: +46313421000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.