Probiotics to Prevent Pneumonia in Critically Ill Kids in the PICU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial will assess whether probiotic supplementation, in addition to standard care, reduces the incidence of ventilator-associated pneumonia among children aged 1 month to 18 years who are critically ill and on mechanical ventilation in the pediatric intensive care unit at Tanta University Hospitals. The study will compare probiotic use with standard management to see if gut bacteria influence infection risk. Early- vs. late-onset VAP will be considered, with awareness of potential antibiotic-resistant pathogens in longer ICU stays. Exclusion criteria include recent enteral vaccines, significant immunosuppression, feeding contraindications, and certain gastrointestinal conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Critically ill children from 1 month to 18 years.
* Both sexes.
* Ventilated not due to chest infection.

Exclusion Criteria:

* Children recently received enteral vaccines.
* Children receiving chronic immunosuppressive such as chemotherapy agents. and immunosuppressive medications, and high dose corticosteroids (more than 1 milligram per kilogram).
* Children with contraindications of enteral feeding.
* Children with gastrointestinal bleeding.
* Children with open wounds following major surgery.
* Children with short gut syndrome.

Where it's running

• Tanta University
  Tanta, Al Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Yomna G El-Feky, MD
• Email: Youmna.elfeky@med.tanta.edu.eg
• Phone: 00201005562005

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.