B Lymphocyte Populations in the Lungs of ICU Patients on Ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will collect endotracheal aspirates from adults in the ICU on invasive ventilation at three timepoints: at intubation, before extubation, and at VAP diagnosis if it occurs. Samples will be analyzed by flow cytometry to describe B lymphocyte populations in the pulmonary microenvironment. The goal is to better understand humoral immune responses in the setting of ventilator-associated pneumonia and host-pathogen interactions that contribute to infection. The study does not specify an intervention and aims to inform future diagnostic or therapeutic approaches by detailing immune cell profiles in the lung. Participants are adults requiring mechanical ventilation for at least five days and without infectious pneumonia or ARDS on admission.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years old), admitted to intensive care under mechanical ventilation for an estimated duration of at least 5 days.

Exclusion Criteria:

* Patients admitted for an infectious pneumonia or presenting with acute respiratory distress syndrome (ARDS). Patients in aplasia (leukocytes \< 0.5 gigal/L).

Where it's running

• CHU Limoges
  Limoges, France Recruiting

Study contacts

• Principal investigator: Julien VAIDIE, Dr — University Hospital, Limoges
• Study coordinator: Safirah Akowanou
• Email: safirah.akowanou@chu-limoges.fr
• Phone: +33555058755

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.