Thermosensitive THBC + CGF for Bone Building After Wisdom Tooth Removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective real-world investigation evaluates the bone-regenerative potential of a thermosensitive hydroxybutyl chitosan–concentrated growth factor (THBC+CGF) in mandibular third molar extractions. Participants with impacted lower third molars and adjacent second molars requiring retention are enrolled and receive one of several repair options, including THBC+CGF, THBC alone, CGF alone, autograft, collagen sponge, or no intervention. Baseline data and intraoperative details are collected, with postoperative clinical exams and imaging to assess bone regeneration. The study aims to clarify the therapeutic efficacy of THBC+CGF in repairing mesial bone defects after M3 extraction in a real-world setting.

Why it matters

Who can join: the full rules

* Inclusion Criteria:
* Preoperative CBCT imaging confirming mandibular third molars (M3s) with low to moderate impaction according to the Pell and Gregory classification, and not in the acute inflammatory stage.
* Ipsilateral mandibular second molars (M2s) with retention value and no indication for extraction.
* Patients able to provide written informed consent and willing to comply with the scheduled follow-up visits.
* Age between 18 and 60 years (inclusive).
* Exclusion Criteria:
* Presence of systemic diseases or other contraindications to tooth extraction surgery.
* Known or suspected current malignancy.
* History of radiation therapy to the head and neck region.
* History of chemotherapy within 5 years prior to surgery.
* Smoking \> 15 cigarettes per day.
* Subjects with mental or neurological disorders, or otherwise unable to provide informed consent.

Where it's running

• Stomatological Hospital Affiliated with Fujian Medical University
  Fuzhou, Fujian, China Recruiting

Study contacts

• Principal investigator: Ye Wu, Ph.D. — Stomatological Hospital Affiliated with Fujian Medical University

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.